摘要
目的观察度洛西汀治疗痛性糖尿病神经病变的治疗效果。方法治疗组应用度洛西汀60mg·d^(-1),对照组起始每晚阿米替林25mg,无效逐渐增加剂量到75mg·d^(-1),疗程8周。观察两组疼痛控制情况及治疗前后VAS评分情况。结果两组患者经治疗1周及8周后疗效比较,治疗组好于对照组,差异有统计学意义和高度统计学意义(P<0.05,P<0.01)。治疗1周和8周后,两组VAS疼痛评分比较显示治疗组评分均低于对照组,差异有高度统计学意义(P<0.01)。结论度洛西汀在痛性糖尿病神经病变治疗上有很好的疗效和安全性。
AIM To investigate the efficacy and safety of duloxetine in the management of diabetic peripheral neuropathic pain.METHODS In a 8-week study,40 patients were randomly assigned to treatment with duloxetine 60 mg·d^（-1）（60 mg,qd） or amitriptyline 25 mg·d^（-1）（25 mg,qd）.The dose of amitriptyline was increased till pain was alleviated or the dose was 75 mg·d^（-1）（75 mg,qd）.The primary outcome was pain relief.The visual analogue scale（VAS） was also compared before and after treatment for 1 and 8 weeks between 2 groups.RESULTS Duloxetine 60 mg·d^（-1） demonstrated statistically significant greater improvement compared with amitriptyline on pain relief,beginning 1 week after randomization and continuing through the 8-week trial.The VAS in the duloxetine group was 8.61±1.21 and 4.36±0.89 and 2.13±0.58 at 0,1,8 weeks,respectively.There was significant reduction in VAS compared with that in the amitriptyline group（P0.01）.CONCLUSION Duloxetine at 60 mg per day is effective and safe in the management of painful diabetic neuropathy.
出处
《中国临床药学杂志》
CAS
2011年第2期89-91,共3页
Chinese Journal of Clinical Pharmacy
关键词
度洛西汀
痛性糖尿病神经病变
阿米替林
duloxetine
diabetic peripheral neuropathic pain
amitriptyline
