摘要
目的观察中药"鼾症一号方"治疗痰瘀互结型阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OS-AS)的临床疗效。方法 30例痰瘀互结型OSAS患者入选为治疗组,另随机选取30例OSAS患者为对照组。除一般性治疗外,治疗组给予"鼾症一号方"治疗3个月,对照组不予其他治疗。比较两组治疗前后中医证素积分和西医睡眠监测指标差异。结果两组中医证素积分、呼吸暂停-低通气指数(AHI)、夜间最低血氧饱和度均有改善,治疗组改善更明显,差异有统计学意义。证候积分,治疗前9.53±1.36比治疗后4.70±1.06,P<0.05;AHI,治疗前33.34±9.01次/小时比治疗后12.28±6.45次/小时,P<0.05;夜间最低血氧饱和度,治疗前69.73%±11.44%比治疗后83.08%±5.36%,P<0.05。对照组前后比较差异无统计学意义,证候积分,治疗前9.07±1.21比治疗后8.87±1.29,P>0.05;AHI,治疗前30.52±5.89次/小时比治疗后27.20±5.99次/小时,P>0.05,夜间最低血氧饱和度,治疗前71.43%±6.67%比治疗后73.62%±6.39%,P>0.05。结论 "鼾症一号方"治疗阻塞性睡眠呼吸暂停综合征疗效可靠,耐受性好,无不良反应。
Objective To evaluate the efficacy of Chinese medical herbs ＂the 1st snoring prescription＂ for phlegm and blood stasis type of obstructive sleep apnea syndrome. Methods Thirty cases of phlegm and blood stasis type patients with OSAS were selected for the treatment group and the other 30 cases of OSAS patients were randomly selected as the control group. In addition to general treatment, the cases in treatment group were given ＂the 1 st snoring prescription＂ for 3 months, while no other treatment to control group. Then integral elements of TCM and Western medicine sleep monitoring indicators were compared between the two groups before and after treatment. Results Two points on integral elements of TCM, apnea - hyperpnoea index （AHI）, lowest nocturnal oxygen saturation were improved in some degree, however these indscators in the treatment group improved more significantly and the difference was statistically significant, with integral elements of TCM, 9.53 ± 1.36 vs 4.70 ± 1.06, P 〈 0.05, AHI, 33.34 ± 9.01 vs 12.28 ± 6.45, P 〈 0.05, lowest nocturnal oxygen saturation, 69.73 % ± 11.44% vs 83.08% ± 5.36% ,P 〈 0.05, and there was no adverse event and toxic effect seen in this group. Whereas there was no significant improvement seen in control group after 3 months, with integral elements of TCM, 9.07 ± 1.21 vs 8.87 ± 1.29, P 〉 0.05 ; AHI, 30.52 ± 5.89 vs 27.20 ± 5.99, P 〉 0.05, lowest nocturnal oxygen saturation, 71.43% ± 6.67% vs 73.62% ± 6.39% , P 〉 0.05. Conclusion Chinese medical herbs ＂ the 1 st snoring prescription＂ was effective for phlegm and blood stasis type of obstructive sleep apnea syndrome,and was well tolerated,with for adverse event and toxic effect.
出处
《医学研究杂志》
2011年第3期80-82,共3页
Journal of Medical Research
基金
福建省教育厅科技基金资助项目(JB10080)
