摘要
目的探讨米非司酮在子宫肌瘤切除术后预防复发中的作用。方法选取2005年7月至2008年6月于山东省郓城县人民医院妇产科行开腹子宫肌瘤切除术后接受米非司酮治疗的86例患者为治疗组,59例无药物治疗为对照组。结果治疗组和对照组术中切除子宫肌瘤数目和最大肌瘤直径比较,差异均无统计学意义(P>0.05);两组术后平均随访时间为(25.8±8.1)个月和(22.5±7.1)个月,治疗组和对照组复发例数分别为14例(16.3%)和16例(27.1%),差异无统计学意义(P>0.05)。治疗组平均复发时间晚于对照组[(10.9±4.6)个月和(7.2±3.1)个月,P<0.05)]。Logistic回归提示,切除子宫肌瘤数目是术后复发最主要的相关因素(P<0.001)。治疗组均出现闭经,12例(14.0%)患者出现食欲不振和恶心,疗程结束后症状消失。结论米非司酮可以推迟和减少子宫肌瘤复发,并可能减少复发几率,但存在一定的副作用,预防子宫肌瘤复发最重要的是术中尽可能完全切除肌瘤。
Objective To analyse the recurrence prevention effect of mifepristone after myomectomy.Methods145 cases underwent laparotomy myomectomy in our department from Jul,2005 to Jun,2008 were analyzed with retrospective cohort study.86 patients received mifepristone postoperative（mifepristore group）and the other 59 patients without mifepristone taking（control group）.ResultsThe number of myoma and diameter of the largest myoma were all not differ much between the two groups（P0.05）.The average follow-up were 25.8±8.1 months and（22.5±7.1）months.The recurrence rates of the mifepristone group and the control were 16.3% and 27.1%（P=0.113）.The average time of recurrence of mifepristone group was later than control group（10.9±4.6）months vs（7.2±3.1）months,P0.05）.Multiple factor analysis showed that the number of myoma was the most important factor related with the recurrence（P0.001）.There were no serious side effect in the mifepristone group.ConclusionsMifepristone could retard the recurrence after myomectomy to some degree.But there were some side effect.The most important factor to reduce the recurrence rate was to find and remove the myomas completely.
出处
《中国妇产科临床杂志》
2011年第2期122-124,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
