摘要
目的探讨雌二醇和口服避孕药前期预处理对体外受精-胚胎移植(IVF-ET)过程中卵巢反应不良患者的意义。方法将2007年1月至2009年2月北京大学第三医院生殖中心152例体外受精-胚胎移植过程中出现卵巢反应不良的患者分为3组,前期分别给予口服避孕药(OCP组)、戊酸雌二醇(E2组)和不给予任何药物(对照组),并对入选患者的临床资料进行分析,评估超促排卵的效果和IVF-ET的结局。结果 OCP组月经第2天>9mm以上卵泡数明显低于对照组(P=0.023),E2组周期取消率明显低于对照组(P=0.028),3组促性腺激素的刺激天数、用药总量、获卵率、受精率和流产率等比较,差异无统计学意义(P>0.05)。结论对卵巢反应不良的患者,IVF-ET前应用OCP和E2可降低周期取消率,临床妊娠率有升高的趋势,口服避孕药和雌二醇预处理对改善卵巢反应不良患者的妊娠结局有益处。
Objective To determine whether the use of oral contraceptive pill（OCP）or luteal phase estrodiol pre-treatment prior to controll ovarian stimulation would improve the pregnancy outcome of poor ovarian response.Methods152 cases with a history of poor ovarian response were randomized into 3 groups：OCP group,patients were given 3-week course of OCP followed by controlled ovarian hyperstimulation（COH）with a standard short protocol;In which E2 group,10-day Estradiol in the luteal phase followed COH with the same protocol and control group,patients were treated with a standard short protocol.ResultsThere were significant difference in more than 9 mm antral follicle on day 2 of the treatment cycle between control group and OCP group（P=0.023）.There were also significant difference in cycle cancel rate between control group and E2 group（P=0.028）.But for the items of number of days of stimulation,total ampoules of gonodortropin（Gn）and peak serum estradiol,number of oocytes retrieved,fertilization rates and pregnancy rates,there were no significant difference among the three groups（P0.05）.ConclusionsPretreatment with an OCP or Estradiol can decrease cycle cancel rates and may improve pregnancy rates,OCP and luteal phase estradiol administration may be beneficial for the patients with a history of poor ovarian response.
出处
《中国妇产科临床杂志》
2011年第2期112-115,共4页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
卵巢反应不良
预处理
体外受精-胚胎移植
雌二醇
口服避孕药
poor ovarian response
pretreatment
in vitro fertilization-embryotransfer
estrodiol
oral contraceptive
