摘要
目的探讨绝经前、后盆底功能障碍性疾病患者阴道壁雌激素受体(ER)与其发生的关系。方法采用免疫组化方法分别测定绝经前、后压力性尿失禁(SUI)患者(SUI组)、盆腔器官脱垂(POP)患者(POP组)、SUI+POP患者(SUI+POP组)阴道壁中ER阳性率,并选择同期绝经前、后各15例因妇科良性疾病而行手术的患者作为对照(对照组)。结果绝经前SUI组、POP组、SUI+POP组和对照组阴道壁组织中ER阳性率分别为44.53%、42.00%、40.53%和66.40%;绝经后SUI组、POP组、SUI+POP组与对照组阴道壁组织中ER阳性表达率分别为29.60%、26.93%、25.60%和47.07%。绝经前和绝经后3组病例组与对照组的ER阳性表达率比较,差异有统计学意义(P<0.05),3组间两两阳性率比较,差异无统计学意义(P>0.05)。结论绝经前后SUI、POP患者阴道壁组织中ER含量明显减少,提示雌激素受体减少可能参与SUI、POP的发生发展。
Objective To explore the relationship between estrogen receptor（ER）in vaginal wall and the occurrence of stress uterine incontinence（SUI）,pelvic organ prolapse（POP）and POP complicated with SUI in patients premenopausal and postmenopausal.MethodsExpression of ER in vaginal wall of premenopausal and postmenopausall patients with SUI（SUI group）,POP（POP group）,SUI ＋ POP（SUI ＋ POP group）was determined by immunohistochemical method.15 premenopausal and postmenopausall patients who underwent vaginal hysterectomy being other benign diseases in the same period acted as control（control group）.ResultsThe positive rate of ER in pre-menopausal SUI group,POP group,SUI ＋ POP group and control group was 44.53%,42.00%,40.53% and 66.40%,respectively.While in post-menopausal SUI group,POP group,SUI ＋ POP group and control group,the rare was 29.60%,26.93%,25.60% and 47.07%.The ER positive rate in SUI group,POP group,SUI ＋ POP group was significant lower than that in control group both pre-and postmenopause.ConclusionsDecrease of estrogen receptor may be related to the occurrence and development of SUI and POP.
出处
《中国妇产科临床杂志》
2011年第2期104-106,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
宁夏自然科学资金项目(NZ09118)支持
关键词
盆腔器官脱垂
压力性尿失禁
雌激素受体
pelvic organ prolapse
stress urinary incontinence
estrogen receptor
