摘要
Kallmann syndrome and normosmic isolated hypogonadotropic hypogonadism （IHH） are developmental disorders characterized by hypogonadotropic hypogonadism that, in the former case, is coupled to loss of the sense of smell. Linkage analyses, deletion mapping and candidate gene approaches uncovered several loci in the pathogenetic mechanism of these diseases （Figure 1） .
Kallmann syndrome and normosmic isolated hypogonadotropic hypogonadism （IHH） are developmental disorders characterized by hypogonadotropic hypogonadism that, in the former case, is coupled to loss of the sense of smell. Linkage analyses, deletion mapping and candidate gene approaches uncovered several loci in the pathogenetic mechanism of these diseases （Figure 1） .
