摘要
目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿手术前、后外周血淋巴细胞亚群的比例,研究手术前及手术后3～6个月患儿淋巴细胞亚群比例的改变情况。方法随机选择30例OSAHS患儿,采集外周静脉血进行淋巴细胞亚群检测,所有患儿均住院在全麻下接受扁桃体联合腺样体等离子切除手术,术后3～6个月进行复查。选取30例年龄性别匹配的、排除相关疾病的健康体检儿童作为对照组。结果 OSAHS组,手术前CD3+CD4+T细胞明显低于手术后及对照组(LSD-t分别为-2.72、-2.56,P均<0.05),CD3+CD8+T细胞明显高于手术后及对照组(LSD-t分别为2.88、2.64,P均<0.05),CD3+CD4+/CD3+CD8+T细胞手术前明显低于手术后及对照组(LSD-t分别为-2.26、-2.14,P均<0.05),CD3+CD4+CD25+T细胞手术前与手术后均高于对照组(LSD-t分别为2.21、2.34,P均<0.05)。结论 OSAHS患儿手术前淋巴细胞亚群比例发生了明显的改变,扁桃体联合腺样体手术后3～6个月外周血淋巴细胞亚群比例恢复正常。
OBJECTIVE To study the peripheral blood lymphocyte subsets changes before and 3 to 6 months after adenotonsillectomy in OSAHS children. METHODS Thirty OSAHS children were randomly recruited. The venous blood samples were taken from the patients 24～48 h before and 3～6 months after adenotonsillectomy. And at the same time, 30 healthy children were selected as control group. RESULTS It was found that the levels of CD4＋ and CD4＋/CD8＋ was lower and the CD8＋ was higher in the pre-operative period of OSAHS children compared with that in control group （P0.05）. There was statistically significant difference between pre- and post-operative levels of CD4＋, CD8＋. The CD4＋, CD25＋ in the pre- and post-operative OSAHS children was higher than that in control group. CONCLUSION The lymphocyte subsets in OSAHS children were significantly changed, and the proportion of lymphocyte subsets returned normal 3～6 months after adenotonsillectomy,
出处
《中国耳鼻咽喉头颈外科》
北大核心
2011年第3期149-152,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
