摘要
奶牛循环系统中高浓度前列腺素F_(2α)(PGF_(2α))是导致早期胚胎死亡的主要原因之一,而早期胚胎死亡又是影响奶牛繁殖力降低的主要因素。最近,牛胚胎中PGF_(2α)受体的发现和定位及PGF_(2α)受体抑制剂降低PGF_(2α)对胚胎发育抑制作用等。研究结果表明,PGF_(2α)受体抑制剂在奶牛繁殖中具有广阔的应用前景。Ghrelin作用在奶牛生殖过程的机理尚不完全清楚,但青年奶牛生殖器官、卵母细胞和早期胚胎中均能检测到Ghrelin、GHSR-1a mRNA及其表达蛋白等。一系列研究结果预示,Ghrelin在奶牛生殖过程中可能作为重要的代谢信号直接参加调控生殖激素的分泌、胚胎发育、生殖道营养物质的运输和生殖道功能的维持等生理过程。
Increased circulating prostaglandin F_（2α）（PGF_（2α））concentrations which induced to early embryonic death were mainly associated with reproductive losses in dairy cows.Recently,some research about the discovery and location of the PGF_（2α） receptor on bovine embryo demonstrated that the bovine embryo was most susceptible to the negative effects of PGF_（2α）.It suggested that prostaglandin F_（2α） receptor antagonist was very valuable for study reproductive performance in lactating dairy cattle.Ghrelin is hormone and an endogenous ligand for the growth hormone secretagogue receptor（GHSR）.So far,although little is known about the effects that ghrelin might be exerting on bovine reproductive processes,both ghrelin and GHSR-1a mRNA and protein have been detected in the ovaries,oviducts,uterus,oocytes and early embryos of Holstein heifers.A series of researches suggested that ghrelin was likely involved in hormone secretion,embryo development,conveying nutritional and metabolic signals to the function of reproductive tract as a metabolic mediator.
出处
《中国奶牛》
2011年第8期26-29,共4页
China Dairy Cattle
基金
湖北省农业科技创新岗位资助
