摘要
目的探讨P53在乳腺癌中的表达及其与预后的关系。方法收集2007～2010年乳腺癌仿根治术标本81例,采用免疫组化法检测乳腺癌中P53、ER、PR和C-erbB-2的表达,并分析P53与预后因子ER、PR和C-erbB-2及淋巴结转移的关系。结果 P53阳性率为84.0%,其表达与预后正性因子ER、PR呈负相关,而与预后负性因子C-erbB-2、腋窝淋巴结转移呈正相关,其差异有统计学意义(P<0.05)。结论 P53高表达是乳腺癌预后的负性相关因子之一。
Objective To explore the expression and prognosis predicting value of P53 in breast cancer.Methods The expressions of P53,ER,PR and C-erbB-2 were detected by IHC method in 81 cases of breast cancer since 2007 to 2010.The correlation between P53 and ER,PR,C-erbB-2 and 1ymphnode metastasis were analyzed.Results The over expression of P53 existed in 68 cases of 81 breast cancer（84.0%）.It was negatively related with prognosis-positive predicting factors such as ER,PR,while positively related with prognosis-negative predicting factors such as C-erbB-2 and lymphnode metastasis.Conclusion In breast cancer,the over expression of P53 is one of the negative prognosis predicting factors.
出处
《中国实用医药》
2011年第9期31-32,共2页
China Practical Medicine
