摘要
目的再次评价多肿瘤标志物蛋白芯片检测系统对肝癌的诊断价值,指导该检测方法在临床诊断中正确应用。方法用多肿瘤标志物蛋白芯片检测系统测定分析96例肝癌患者,93例良性肝病患者和90例健康人血清中12种肿瘤标志物（CA19-9、NSE、CEA、CA242、CA125、CA153、AFP、Fer-ritin、f-PSA、PSA、β-HCG、HGH）的水平。结果通过统计分析,发现AFP、CA242、Ferritin、CA19-9四种标志物水平在肝癌组比良性肝病组明显升高,差别具有统计学意义;采用上述四项标志物联合检测的阳性率为75%,高于该检测系统中任何单一指标的阳性率。结论本研究中多肿瘤标志物蛋白芯片检测系统联合检测肝癌的敏感度仅提高至75%,低于多篇文章报道的所能达到的敏感度82.89%~91.6%。
Objective To re-evaluate the diagnostic value of multi-tumor marker protein biochip detective system for liver cancer,and to guide the proper application of the detection method in clinical diagnosis.Methods Using the multi-tumor markers protein biochip detective system to determine and analyze the concentration values of 12 tumor markers（CA19-9,NSE,CEA,CA242,CA125,CA153,AFP,Ferritin,f-PSA,PSA,β-HCG,HGH） in the serum levels of 99 liver cancer patients,93 benign liver disease patients and 90 healthy persons.Results By statistical analysis,we found that the concentrations of AFP,Fer,CA19-9,CA242 were all higher in the PHC group than in the non-PHC groups;the difference was significant;combined measurement of the above-mentioned four kinds of indicators,the positive ratio was 75%,had higher sensitivity than single tumor marker in the detective system.Conclusion In this study,adopting the multi-tumor marker protein chip detection system,the sensitivity of combined detection of liver cancer was only increased to 75%,lower than the sensitivity of 82.89%~91.6%,compared to more articles.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第3期294-297,共4页
Cancer Research on Prevention and Treatment
关键词
肝癌
肿瘤标志物
蛋白芯片
Liver cancer
Tumor marker
Protein biochip
