摘要
目的探讨青年肺癌的临床特征及影响预后的因素。方法回顾性分析60例40岁以下肺癌患者的临床资料,分别对性别、年龄、吸烟史、病理类型、肿瘤部位、肿瘤大小、TNM分期、有无肿瘤家族史及治疗方法进行预后分析。Kaplan-Meier法计算生存率,Log-rank进行生存率显著性检验,Cox比例回归风险模型进行单因素、多因素分析,评价各因素对预后的影响。结果全部青年肺癌患者的1、2、3年生存率分别为:69.1%、50.0%、20.0%。单因素分析显示:病理类型(P=0.001)、吸烟史(P=0.0461)、TNM分期(P=0.0383)、治疗方法的选择(P=0.011)是影响预后的因素。多因素分析则显示:病理类型和TNM分期是影响预后的独立因素。结论青年肺癌的临床表现无特异性,提高对青年肺癌的认知程度,争取早期正确诊断,选择正确的治疗方法,是提高生存率的方法。
Objective To investigate the characteristics of lung cancer in young patients and analyze the corresponding prognostic factors.Methods We retrospectively reviewed the clinical data from 60 cases of lung cancer,aged fewer than 40,diagnosed by pathology or cytology.Gender,age,smoking history,pathology,tumor location and size,TNM stage,familial cancer history and the choice of treatment were analyzed for their relationships to prognosis.The survival rate was calculated by Kaplan-Meier method and Log-rank test was used to compare the survival rate.Univariate and multivariate factors for survival were analyzed by Cox proportional hazards regression model.Results The overall 1-,2-,and 3-year survival rates were 69.1%,50.0%and 20.0% respectively.Cox univariate analysis revealed that type of pathology,smoking history,TNM stage,the choice of treatment were prognostic factors.Cox multivariate analysis revealed that type of pathology,TNM stage were independent prognostic factors for young patients with lung cancer.Conclusion The characteristics of lung cancer in 60 young patients had no specificity.Being aware of young cases of lung cancer,striving for an early correct diagnosis and choosing correct treatment would be the ways to improve survival rate.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2011年第3期274-277,共4页
Cancer Research on Prevention and Treatment
关键词
肺癌
青年患者
预后因素
Lung cancer
Young cases
Prognostic factors
