期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

探讨心肌缺血修饰白蛋白对心肌梗死溶栓后心肌再灌注的评价作用 被引量：3

原文传递
导出
摘要 目的观察ST段抬高型心肌梗死(STEMI)患者溶栓前后血管再通和心肌缺血修饰白蛋白(IMA)浓度变化,探讨IMA对STEMI溶栓后再灌注的预测作用。方法入选发病6h之内入院STEMI患者共50例,均予常规及尿激酶溶栓治疗,根据2h后有无再灌注表现将患者分成无灌注组(17例)和再灌注组(33例),两组患者于溶栓前及溶栓后2h、4h、6h分别采血测IMA浓度,并于8h、12h、14h采血测肌酸激酶同工酶(CK-MB)浓度进行对照。结果两组患者溶栓前IMA浓度无明显差异,溶栓后4～6hIMA浓度有显著差异(P<0.05);再灌注组IMA于心肌再灌注恢复后,提前达峰值并回落至正常,IMA达峰值时间较CK-MB显著提前(P<0.05)。结论 STEMI溶栓后心肌是否恢复再灌注与IMA浓度变化存在相关性。IMA早期明显下降可作为STEMI溶栓后心肌恢复有效再灌注的指标。
作者 刘鹏 李丹 蒲晓群 欧阳泽伟 石向江
机构地区 邵阳市中心医院心内科 湘雅医院心内科
出处 《中华临床医师杂志（电子版）》 CAS 2011年第5期141-143,共3页 Chinese Journal of Clinicians(Electronic Edition)
关键词 心肌梗死 心肌再灌注 溶栓 缺血修饰白蛋白
分类号 R542.22 [医药卫生—心血管疾病]
  • 相关文献

参考文献12

  • 1马长生.冠心病介入治疗.2 版,北京:人民卫生出版社,2005:68-69.
  • 2李萍,王化芬,崔庆,刘慧.缺血修饰白蛋白的检测在急性冠脉综合征早期诊断中的意义[J].临床军医杂志,2008,36(5):684-685. 被引量：4
  • 3裴德安,徐默玲,郑义通,胡世文.急性心肌梗死患者血清磷酸激酶同功酶、肌钙蛋白Ⅰ及肌红蛋白浓度变化的比较研究[J].心脏杂志,2000,12(4):287-288. 被引量：2
  • 4Bar-Or D,Lau E,Winkler JV.A novel assay for cobaltalbumin binding and its potential as a marker formyocardial ischemia-a preliminary report.J Emerg Med,2000,19:311-315.
  • 5Bhagavan NV,Lai EM,Rios PA,et al.Evaluation of human serum albumin cobalt binding assay for the assessment ofmyocardial ischemia and myocardial infarction.Clin Chem,2003,49:581-585.
  • 6Apple FS,Quist HE,Otto AP,et al.Release characteristics of cardiac biomarkers and ischemia2modified albumin as measured by the albumin cobalt-binding test after a marathon race.Clin Chem,2002,48:1097-1100.
  • 7Roy D,Quiles J,Sharma R,et al.Ischemi-amodified albumin concentrations in patients with peripheral vascular disease and exercise induce dskeletal muscle ischemia.Clin Chem,2004,50:1656-1660.
  • 8张东玲,朱广博,郭禹,刘蕊.缺血修饰清蛋白诊断急性冠脉综合征临床应用实验研究[J].现代检验医学杂志,2007,22(3):23-25. 被引量：10
  • 9Roy D,Quiles J,Gaze DC,et al.Role of reactive oxygen species on the formation of the novel diagnostic marker ischaemia modified albumin.Heart,2006,92:113-114.
  • 10Ferrari R,Ceconi C,Curello S,et al.Ischemic Preconditioning,myocardial stunning,and hibernation:basic aspects.Am Heart J,1999,138:S61-68.

二级参考文献12

  • 1急性心肌梗塞溶栓疗法参考方案（1996年7月修订）[J].中华心血管病杂志,1996,24(5):328-329. 被引量：1319
  • 2颜红兵 柯元南.急性心肌梗死直接冠状动脉介入治疗中的无复流现象研究[J].中华心血管病杂志,2003,31:21-23.
  • 3Chan B,Dodsworth N,Woodrow J,et al.Site-specific N-terminal autodegradation of human serum albumin[J].Eur J Biochem,1995,277 (1～2):524-528.
  • 4Bar-Or D,Curtis G,Rao N,et al.Characterization of the Co^2+ and Ni^2+ binding amino-acid residues of the N-terminus of human albumin[J].Eur J Biochem,2001,268(1):42.
  • 5Bar-Or D,Lau E,Winkler JV.A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia-a preliminary report[J].Emerg Med,2000,19:311-315.
  • 6Apple FS,Quist HE,Otto AP,et al.Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race[J].Clin Chem,2002,48:1109-1100.
  • 7Pollack CV Jr,Peacock W F,Summers R W,et al.Ischemia-modified albumin (IMA) is useful in risk stratification of emergency department chest pain patients[J].A Cad Emerg Med,2003,10(5):555-556.
  • 8Roy D,Quiles J,Aldama G,et al.Ischemia modified albumin for assessment of patients presenting to the emergency department with acute chest pain but normal or non-diagnostic 12-lead electrocardiograms and negative cardiac troponin T[J].Int J Cardiol,2004,97(2):297-301.
  • 9Fuster V, Badin on L, Badin on JJ, et al. The pathogencsis of coronary arlery disease and the acute coronary syndromes[ J ]. N Engl J Med, 1992,326:242 - 250.
  • 10Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin Binding and its potential as a marker for myocardial ischemia a pre-Liminary report[J]. J Emcrg Med,2000,19(4):311.

共引文献17

同被引文献39

  • 1Lippi G, Montagnana M, Salvagno GL, et al. Potential value for new diagnostic markers in the early recognition of acute coronary syndromes [J]. CJEM ,2006,8( 1 ) :27 -31.
  • 2Bar - Or D, Curtis G, Rao N, et at. Characterization of the Co2 + and Ni2 + binding amino - acid residues of the N - terminus of human albumin [ J ]. Eur J Biochem,2001,268 ( 1 ) :42 - 47.
  • 3Luo Y, Wang C, Jiang T, et al. Interference - free determination of I schemia - modified albumin using quantum clot coupled X - ray fluo- rescence spectroscopy [ J ]. Biosens Bioeleetron, 2014, 51 C: 136 - 142.
  • 4da Silva SH, Pereira Rda S, Hausen Bdos S, et al. Assessment of the nickel - albumin binding assay for diagnosis of acutecoronary syn- drome[ J ]. Clin Chem Lab Med ,2011,49(3 ) :541 - 546.
  • 5Hausen BS, Signor C, Kober H, et at. Effect of temperature on albu- min cobalt binding and its influence on ischemia - modified albumin levels in patients with suspected acute coronary syndrome [ J ]. Clin Lab,2012,58 ( 1 - 2) : 169 - 172.
  • 6Christenson RH, Duh SH, Sanhai WR, et al. Characteristics of an album in cobalt bindingtest for assessment of acute coronary syndrome patients : a muhicenter study [ J ]. Clin Chem, 2001,47 ( 3 ) : 464 - 470.
  • 7Sygitowicz G, Janas J, Biaek S, et al. Ischaemia modified albumin in patients with acute coronary syndrome and negative cardiac troponin I [J]. Scand J Clin Lab Invest,2013,73(2) :130 -134.
  • 8Pollack CV, Jr IV, Summers RW, et al. Ischemia- modified albu- min (IMA) is useful in risk stratification of emergency department chest pain patients [ J ] Acad Emerg Med ,2003,10 ( 5 ) :555 - 556.
  • 9Van Belle E, Dallongeville J, Vicaut E, et al. Ischemia - modified albumin levels predict long - term outcome in patients with acute my- ocardial infarction. The French Nationwide OPERA study [ J ]. Am Heart J ,2010,159 (g) :570 - 576.
  • 10Quiles J, Roy D, Gaze D, et al. Relation of ischemia - modified al- bumin (IMA) levels following elective angioplasty for stable angina pectoris to duration of balloon - induced myocardial ischemia [ J ]. Am J Cardiol, 2003,92 ( 3 ) : 322 - 524.

引证文献3

二级引证文献9

中华临床医师杂志（电子版）
2011年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部