摘要
目的探讨放射性核素肾动态显像测定肾小球滤过率(GFR)的影响因素,以及放射性滞留致GFR高估的影响及解决方法。方法在GFR测定过程中,选择显像剂的注射质量和本底感兴趣区(ROI)的两种常见因素,在规范操作的基础上观察其影响;对放射性核素滞留的患肾分别采用全肾ROI勾画法和肾皮质ROI勾画法处理,比较两种方法对GFR测定的准确性。结果本底ROI的位置选择对GFR有影响;"弹丸"注射质量将直接影响肾血流灌注与患者病情的一致性,只有高质量的"弹丸"是获得真实GFR的前提;当放射性核素滞留时使用全肾ROI勾画法会高估肾功能,使用肾皮质ROI勾画法能得到真实准确的GFR值。结论在肾动态显像测定GFR值的整个过程中,显像剂的注射质量和本底ROI的选择,以及放射性核素滞留时ROI的勾画和滞留区的扣除对GFR的测定有着明显的影响,因此测定方法的进一步完善和操作流程的标准化,是获得GFR准确结果的重要保证。
Objective To investigate the factors influenced dynamic radionuclide renal imaging measurement of glomerular filtration rate（GFR）,and radioactive retention caused overestimation of GFR and solutions.Methods In the course of GFR determination,the imaging agent injection for the quality and selection of the background region of interest（ROI） which were two common factors were observed the effects on the basis of the standard operation;on the risk of renal retention of radionuclides were used to the whole kidney ROI outline methods and treatment of renal cortical ROI outline to compare two methods of GFR measurement accuracy.Results The choice of the location of the end of GFR ROI impact;＂shot＂ injection of quality directly affected the renal blood flow and consistency of patients′ condition,only the high quality of the ＂shot＂ is a prerequisite to obtain the true GFR;when the radioactive retention factors outlined the use of the whole kidney ROI method may overestimate the renal function,using the method outlined in renal cortex ROI could get the true and accurate GFR values.Conclusion Renal dynamic imaging analyzing results of GFR may be affected by several factors,of which should be the quality of imaging agent injection and the choice of the background ROI,and the ROI of radionuclide retention and detention areas outlined deduction,which affect GFR value apparently.Therefore,further improvement of determination and standardization of operational processes is important to obtain accurate results GFR guarantees.
出处
《新疆医科大学学报》
CAS
2011年第3期305-309,共5页
Journal of Xinjiang Medical University
关键词
放射性核素
动态显像
肾小球滤过率
radioactive nuclide
dynamic imaging
glomerular filtration rate（GFR）
