摘要
目的：揭示慢性牙周炎患者血浆β-防御素-3浓度的变化,探讨其与慢性牙周炎患病危险性的相关性。方法：收集慢性牙周炎患者作为牙周炎组,共78例。收集同期牙周健康者作为对照组,共40例。ELISA检测血浆β-防御素-3浓度。统计分析其与慢性牙周炎患病危险性的相关性。结果：协方差分析显示,牙周炎组血浆β-防御素-3浓度（87.3±39.5pg/ml）显著低于对照组（152.8±29.9pg/ml）（F=7.701,P〈0.05）。经Spearman相关分析,牙周炎组血浆β-防御素-3浓度与牙周探诊深度（r=-0.359,P〈0.05）、附着丧失（r=-0.317,P〈0.05）和出血指数（r=-0.301,P〈0.05）均显著负相关。Logistic回归分析显示,血浆β-防御素-3浓度（OR=0.391,95%CI=0.257~0.812,P〈0.05）是罹患慢性牙周炎的独立危险因素。ROC曲线分析显示,血浆β-防御素-3浓度预测罹患慢性牙周炎有显著预测价值（曲线下面积=0.819,95%CI=0.763~0.855,P〈0.001）,且判定血浆β-防御素-3浓度〈123.9pg/ml,对预测罹患慢性牙周炎有74.4%的灵敏度和70.0%的特异度。结论：慢性牙周炎患者血浆β-防御素-3水平降低,血浆β-防御素-3水平降低可能是侵袭性牙周炎的危险因素。
Objective Change of plasma beta-defensin-3 level was determined in patients with chronic periodontitis and its correlation with disease was evaluated.Methods 78 consecutive patients with chronic periodontitis and 40 healthy controls were enrolled into this study.Plasma beta-defensin-3 concentration was measured by ELISA.Its Correlation with disease was analyzed statistically.Results The plasma beta-defensin-3 level（87.3±39.5 pg/ml） in patients was significantly lower than that（152.8±29.9 pg/ml） in healthy controls（P0.05）.Spearman correlation coefficient showed that probing depth（r=-0.359,P0.05）,attachment loss（r=-0.317,P0.05） and bleeding index（r=-0.301,P0.05） were negatively related to plasma beta-defensin-3 level in the patients with chronic periodontitis.On a multivariate logistic regression,plasma beta-defensin-2 level（OR=0.391,95%CI=0.257~0.812,P0.05） was an independent variable predicting chronic periodontitis.A receiver operating characteristic curve identified that a plasma beta-defensin-3 level123.9 pg/ml predicted chronic periodontitis with 74.4% sensitivity and 70.0% specificity（area under curve=0.819,95%CI=0.763~0.855,P0.001）.Conclusion Decreased beta-defensin-3 is found after chronic periodontitis and low beta-defensin-3 may be independently associated with chronic periodontitis.
出处
《放射免疫学杂志》
CAS
2011年第2期207-209,共3页
Journal of Radioimmanology
