摘要
目的了解南京市秦淮区高中一年级及初中一年级乙肝病毒表面抗原携带状况、评价1992年乙肝疫苗纳入计划免疫管理后的免疫效果。方法对两个年级学生采集3ml静脉血分离血清,采用酶联免疫吸附法(ELISA)检测HBsAg、抗-HBs、抗-HBc、HBeAg、抗-HBe。率的比较采用χ2检验,P<0.05为差异有统计学意义。结果 HBsAg总阳性率为1.10%,男女分别为0.66%和1.46%,差异无统计学意义。单抗-HBs阳性率为34.51%,高中及初中年级组分别为28.71%和43.76%,差异有统计学意义。结论乙肝疫苗纳入计划免疫管理17年以来,乙肝病毒表面抗原阳性率已降到较低水平,随着年龄的增加单抗-HBs阳性率逐渐下降,且下降较明显,应及时进行加强免疫。
Objective To investigate the current situation of HBV carrier and Anti-HBs among teenagers and evaluate the immune effectiveness of Expanded Program of Immunization（EPI） initiated in 1992 in Nanjing city.Methods A cluster sampling method was used for the study.The first year students of middle and high school had blood tested for HBsAg,anti-HBs,anti-HBc,HBeAg and anti-HBe with enzyme linked immunosorbent assay.Results The prevalence rate of HBsAg among investigated students was 1.1%,with 0.66% in male and 1.46% in female respectively.The positive rate of anti-HBs was 34.51% on average,with 28.71% in high school students and 43.76% in middle school students.There were no significant differences in the prevalence of HBV infection and the positive rate of Anti-HBs between genders and in the two age groups.Conclusion The prevalence of HBV infection has decreased to the low level with 17 years implementation of EPI.However,the low positive rate of anti-HBs suggested the requirement of timely hepatitis B boost shot for teenagers.
出处
《中国预防医学杂志》
CAS
2011年第4期330-332,共3页
Chinese Preventive Medicine
