摘要
目的探讨中国北方地区汉族人生长转化因子(TGF)基因型别的多态性与多发性骨髓瘤(MM)的相关性。方法对21例MM患者采用顺序特异性引物-聚合酶链反应(PCR-SSP)方法,检测TGF基因型别的多态性变化,并与35名健康献血者对照组进行对比分析。结果 MM组TGF(H)等位基因频率(38.09%)显著高于正常对照组(11.43%),P<0.05;提示该等位基因频率增高与MM的发病相关;而TGF其它等位基因频率在MM组和对照组中无明显差异。结论我国北方地区汉族人TGF(H)基因与MM的易感性相关联。
Objective：To study the relationships between TGF genotype in Northern Chinese and patients with MM.Methods：TGF genotypes polymor phism were analyzed by Polymerase Chain Reaction-Special Sequence Primer（PCR-SSP） in 21 MM patients,and 35 controls.Results：The frequency of TGF（H） genotype was significantly higher in MM patients than controls（P0.05）.The TGF（H） genotype has significant influence on MM.Conclusion：TGF（H） genotype in Northern Chinese positively related to MM and most likely contributes to high risk for MM.
出处
《中国优生与遗传杂志》
2011年第4期29-30,共2页
Chinese Journal of Birth Health & Heredity
