摘要
采用AMI方法计算了环境致癌物1.2-环氧3,4-丁烯(EB)和1,2,3,4二环氧丁烷(DEB)与DNA鸟嘌呤反应过程速率控制步骤的活化能及DEB与DNA片段生成烷化交联产物的结构和能量、结果得出:用烷化反应的难易程度难以解释DEB的致突性比EB大100倍的实验事实;强致突的DEB可与鸟嘌吟发生两次烷化反应,生成DNA交联产物,交联后的DNA结构稳定、变形小:而EB则不能交联.这可能为两者基因毒性差异巨大的分子机制.
The reaction of 1,2-epoxy-3,4-butene(EB)and l,2,3,4-diepoxybutane(DEB),the metabolites of rodent carcinogenic 1,3-butadiene, and guanine and fragment of DNA have been computed. The results show that those activation energies have not big difference, so it is difficult to explain the fact that the mutagenicity of DEB is 100 times greater than that of EB by the activity of alkylating reaction . It is also show that DEB can cross-h'nking with DNA through two times alkylating reactions with guanine and cross-linking DNA deforms little comparing with nature DNA. But EB cannot. So, this difference may contributes to the significant different carcinogenicity of two agents.
出处
《环境化学》
CAS
CSCD
北大核心
1999年第5期427-431,共5页
Environmental Chemistry
基金
国家自然科学基金(批准号:29377269)资助项目
