摘要
目的肝炎合剂1号对α-萘异硫氰酸酯(ANIT)所致小鼠急性黄疸模型的退黄降酶作用。方法将小鼠随机分为正常组、模型组、阳性药物对照组(茵栀黄注射液)和提取液大、中、小给药组。各治疗组连续灌胃给药7d后,ANIT诱发黄疸模型,48h后摘眼球取血,分离血清,以血清肝功能指标以及肝脏组织病理学的改变为观察指标。结果与模型组比较,茵栀黄组、合剂小剂量给药组的ALT、AST、ALP、TBIL、IBIL,均显著下降(P<0105);与茵栀黄组比较,合剂小剂量给药组ALT、AST、ALP、TBIL、IBIL,均无差异(P>0.05)肝脏病理组织学检查表明,合剂能明显减轻肝细胞变性、坏死和肝小胆管增生。结论合剂具有降低黄疸小鼠血清胆红素、转氨酶和改善肝脏组织损伤的作用。
Objective To observe the action of Pharmacodynamics of No.1 Hepatitis Mixture on reduced jaundice and enzyme in jaundice model of mice induced by AN IT.Methods Mice were at random divided into six groups：group A in which no treatment was given,group B in which AN IT was given on the seventh day,group D in which low dosage of＂Mixture＂ was given,group E in which moderate dosage of＂＂Mixture＂was given,group F in which high dosage of Mixture was given,and group C in which＂Yinzhihuang injection＂was given as positive control.Except group A and B,the other group s were given corresponding medicines for 7 days and then additionally administered AN IT to induced jaundice.After 48 h,the mice blood was gained from eyes.The serum was separated.The liver functional sign and the content of ALT,AST and ALP in serum,and the change in pathology of liver tissue were observed.Results Compared to group B,ALT,AST,ALP,TB IL,IB IL of group C and D group dropped obviously（P〈0105）;Compared to group C,ALT,AST,ALP,TB IL,IB IL of group D group dropped obviously（P〉0.05）;by the examination the liver pathology,we found that＂Mixture＂could notably alleviate hepatica change and necrosis and hepatominicholange hyper plasma.Conclusions ＂Mixture＂has the action of reducing serum biliru-bin and improving liver tissue injury in rats of experimental cholestasis.
出处
《齐齐哈尔医学院学报》
2011年第1期4-6,共3页
Journal of Qiqihar Medical University
关键词
中药肝炎合剂1号
茵栀黄注射液
灌胃
肝功能
No.1 Hepatitis Mixture Yinzhihuang injection Intragastric administration Liver function
