摘要
目的探讨七氟醚肺活量法吸入诱导和丙泊酚静脉诱导对顺式阿曲库铵起效时间的影响。方法择期行胸外科或普外科手术的全麻患者60例，ASAⅠ或Ⅱ级，年龄18-65岁，随机均分为七氟醚组（S组）和丙泊酚组（P组）。麻醉诱导：P组静脉注射咪达唑仑0．05mg／kg、芬太尼2μg／kg、丙泊酚1mg／kg；S组采用肺活量吸入法，七氟醚吸入浓度8％。两组患者意识消失后均给予顺式阿曲库铵0．15mg／kg。监测肌松药起效时间，意识消失时间，血流动力学指标，并评价气管插管条件。结果患者意识消失时间、顺式阿曲库铵起效时间S组明显短于P组（P〈0．05或P〈0．01）。插管引起的心血管反应S组小于P组（P〈0．05）。结论七氟醚吸入诱导能明显缩短顺式阿曲库铵的起效时间，且循环功能稳定。
Objective To compare the induction quality of intravenous propofol and inhalational sevoflurane on the skelaxin onset time of cis--atracurium. Methods Sixty ASA Ⅰ or Ⅱ patients,aged from 18 to 65, undergoing selective surgery with general anesthesia, were equally randomized into two groups, group P with intravenous propofol, group S with inhalational sevoflurane. Group P： intravenous induction with midazolam 0.05 mg/kg, fentanyl 2 μg/kg, propofol 1 mg/kg. Group S： inhalation of 8% sevoflurane in vital capacity respiration. 0. 15 mg/kg cis-atracurium was infused after loss of consciousness in both groups. Time for loss of eyelash reflex, hemodynamic changes, onset time of cis-atracurium and conditions of tracheal intubation were recorded. Results The time to loss of eyelash reflex in group S is significantly shorter than that in group P（P〈0. 05）. The onset time of cisatracurium in group S is significantly shorter than that in group P （P〈0.01）. Tracheal intubation causes less stress response in group S than in group P（P〈0.05）. Conclusion Sevoflurane induction can greatly shorten the onset time of cis-atracurium with stable hemodynamic state.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2011年第4期366-368,共3页
Journal of Clinical Anesthesiology
