摘要
目的探讨乌司他丁对慢性阻塞性肺疾病急性加重期(AECOPD)炎性细胞因子的影响。方法慢性阻塞性肺疾病急性加重患者随机分为两组,治疗组在综合治疗基础上加用乌司他丁,对照组为综合治疗,治疗前后观察血清细胞因子(IL-8、TNF-α、IL-6)的变化。结果两组治疗后均能降低血清TNF-α、IL-8、IL-6的表达,且治疗组优于对照组。结论乌司他丁能降低AECOPD患者血清中IL-8、TNF-α、IL-6的表达。
Objective To investigate the influence of Ulinastain on the level of TNF-α,IL-6,IL-8 in the chronic obstructive pulmonary disease（COPD）.Methods The patients were randomly divided into two groups.The treatment group took Ulinastain based on the comprehensive therapy and the control group was given comprehensive therapy.The changes of serum cytokines（TNF-ɑ,IL-6,IL-8） were observed before and after the treatment.Results After the treatment,both groups improved the expression of TNF-ɑ,IL-6,IL-8.The treatment group was superior to the control group.Conclusions Ulinastain can suppress airway inflammatory in AECOPD.
出处
《医药论坛杂志》
2011年第3期121-122,共2页
Journal of Medical Forum
