摘要
目的：观察原发性高血压（ Ｅ Ｈ）患者的血管紧张素转换酶（ Ａ Ｃ Ｅ）水平及其基因型的关系。方法：测定了４５例 Ｅ Ｈ 患者、４３例冠心病（ Ｃ Ｈ Ｄ）患者和４３例健康志愿者血浆 Ａ Ｃ Ｅ水平、 Ａ Ｃ Ｅ 基因型及血浆血管紧张素Ⅱ（ Ａ ＴⅡ）水平。结果：① Ｅ Ｈ、 Ｃ Ｈ Ｄ 和健康对照的各组具有 Ａ Ｃ Ｅ 基因 Ｄ Ｄ型者，血浆 Ａ Ｃ Ｅ水平都高于同组的 Ｉ Ｉ基因型（ Ｐ ＜ ０．００１）和 Ｉ Ｄ 基因型（ Ｐ ＜ ０．０１）；② Ｅ Ｈ Ⅱ期患者中 Ｄ Ｄ 基因型者血浆 Ａ Ｃ Ｅ 水平也高于 Ｉ Ｉ基因型者（ Ｐ ＜ ０．０５），但 Ｅ Ｈ Ⅲ期患者中 Ｄ Ｄ 基因型者，血浆 Ａ Ｃ Ｅ水平和 Ｉ Ｉ、 Ｉ Ｄ 基因型者都无明显差别（ Ｐ ＞ ０．２）；③血浆 Ａ ＴⅡ浓度与 Ａ Ｃ Ｅ 基因型无明显关系。结论：无论 Ｅ Ｈ、 Ｃ Ｈ Ｄ 或健康人，凡具有 Ａ Ｃ Ｅ 基因 Ｄ Ｄ 型的个体，其血浆 Ａ Ｃ Ｅ 水平均有升高，而 Ｉ Ｉ基因型则较低。
Objective:To observe relationship between plasma ACE levles and ACE gene polymorphism on patients with essential hypertension (EH) and coronary heart disease (CHD).Method:The polymerase chain reaction (PCR),ultraviolet method and radioimmunoassay were used to determine the I/D polymorphism in the ACE gene,plasma ACE levels and angiotensin Ⅱ (AngⅡ) concentration in 36 patients with EH,43 patients with CHD and 43 age matched healthy volunteers.Results:① In all individuals carried ACE gene DD genotype in patients with EH,CHD and control group plasma ACE levels presented strict increase compared with insertion genotype in each group (P< 0.001 ).②In stage Ⅱ patients with EH having ACE gene DD genotype plasma ACE levels still were higher compared with II genotype (P< 0.05 ),but in stage Ⅲ patients with EH having DD genotype plasma ACE levels obviously decreased and no differ to II,ID genotype (P> 0.2 ) .③Plasma AngⅡ concentration had no association with ACE gene polymorphisms.Conclusion:Plasma ACE levels of all individuals having ACE gene DD genotype were highest among either patients with EH and CHD or healthy persons,but in II genotype were at lowest.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1999年第8期363-365,共3页
Journal of Clinical Cardiology
关键词
血管紧张素
转换酶
基因
高血压
ACE
Angiotensin converting engyme gene Angiotensin converting enzyme Hypertension
