摘要
目的：探讨急性心肌梗死（ Ａ Ｍ Ｉ）患者血清一氧化氮（ Ｎ Ｏ）含量变化及其临床意义。方法：在２８例 Ａ Ｍ Ｉ患者接受尿激酶静脉溶栓治疗前及治疗后３ ｈ 分别测定其血清一氧化氮（ Ｎ Ｏ）、超氧化物岐化酶（ Ｓ Ｏ Ｄ）及丙二醛（ Ｍ Ｄ Ａ）的含量变化。结果：溶栓治疗后３ ｈ 的 Ｎ Ｏ、 Ｓ Ｏ Ｄ 含量较治疗前含量显著减少（ Ｐ ＜ ０．０５）。 Ｍ Ｄ Ａ 含量显著增加（ Ｐ ＜ ０．０５）。尤以冠状动脉再通组 Ｎ Ｏ、 Ｓ Ｏ Ｄ 含量减少（ Ｐ ＜ ０．０１）， Ｍ Ａ Ｄ 含量增加（ Ｐ ＜ ０．０１）更明显。而未通组在治疗前后的 Ｎ Ｏ、 Ｓ Ｏ Ｄ、 Ｍ Ｄ Ａ 含量无显著性差异（ Ｐ ＞ ０．０５）。结论： Ｎ Ｏ、 Ｓ Ｏ Ｄ 含量减少， Ｍ Ａ Ｄ 含量增加与缺血心肌再灌注损伤有关，在对 Ａ Ｍ Ｉ患者行溶栓治疗同时，应同时积极采取抗氧化治疗。
Objective:To study the clinical significance of changes in plasma nitric oxide (NO) levels in patients with acute myocardial infarction (AMI) treated by intravenous thrombolytic therapy.Method:In 26 cases of acute myocardial infarction (AMI) thrombolytic treatment with intraveneous urokinase was given. Before thrombolysis and 3 hours after thrombolysis NO,SOD and MDA in blood plasma were determined.Result:At 3 hours after thrombolytic therapy compared with before thrombolytic therapy, NO and SOD in plasma were decreased (P< 0.05 ), MDA in plasma was significantly increased (P< 0.05 ).NO and SOD were more singnificantly decreased (P< 0.01 ) in reperfused group. While MDA was more singnificantly increased (P< 0.01 ).The change of NO, SOD and MDA levels in blood plasma of nonreperfused group had no statistical significance (P> 0.05 ) before and after thrombolytic therapy.Conclusion:The decrease in plasma NO,SOD and increase in MDA are likely associated with myocardial ischemia reperfusion injury.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1999年第8期346-348,共3页
Journal of Clinical Cardiology
关键词
心肌梗塞
一氧化氮
溶栓疗法
AMI
Myocardial infarction Nitric oxide Thrombolytic therapy
