摘要
目的：研究心力衰竭（简称心衰）患者外周血淋巴细胞β１ 受体基因变化的意义。方法：采用逆转录多聚酶链反应（ Ｒ Ｔ Ｐ Ｃ Ｒ）方法测定６０例心脏病患者及２０例健康人的外周血淋巴细胞 β１ｍ Ｒ Ｎ Ａ 水平。结果：①外周血淋巴细胞β１受体ｍ Ｒ Ｎ Ａ 水平随心功能分级增高而下降；②这种变化出现较早，心功能Ⅱ级时已很明显，心功能Ⅳ级时可下降５０以上；③β１ 受体 ｍ Ｒ Ｎ Ａ 水平随患者年龄增加、病程延长、左室质量增加、左室舒张功能减退而下降，与体重指数、血压、血脂、血糖等关系不明显。结论：用 Ｒ Ｔ Ｐ Ｃ Ｒ 技术检测外周血淋巴细胞 β１受体对评价心衰患者的病情有一定参考价值。
Objective:To study the value of peripheral blood lymphocytic β 1 receptor mRNA in patient with heart failure (HF).Method:The peripheral blood lymphocytic β 1 receptor mRNA was determined in 60 cases with CHF and 30 normal controls by RT PCR method.Result:①The reduction of β 1 adrenergic receptor mRNA might contribute to further loss of cardiac function;②The reduction was already beginning in cardiac function class Ⅱ,and about 50% reduction in cardiac function class Ⅳ;③The reduction correlated well with increased age,disease history left ventricular mass and decreased left ventricular diastolic function.Conclusion:The pevipheal blood lymphocytic β 1 receptor mRNA determined by RT PCR method may be an useful index for evaluating clinical condition of HF patient.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1999年第8期339-342,共4页
Journal of Clinical Cardiology
