摘要
目的探讨女性不孕症患者抑郁症状及与机体细胞免疫相关性。方法采用自评抑郁量表(SDS)对214例女性不孕症患者进行抑郁障碍量化评分检查,应用流式细胞术测定部分患者外周血T细胞亚群,分析比较不孕症伴抑郁组与不孕症非抑郁组外周血T细胞亚群的差异。结果女性不孕症伴抑郁者SDS评分高于不孕非抑郁者和全国常模者(P<0.05);不孕症非抑郁者与正常对照者相比CD3+T细胞、CD4+T细胞和CD4+/CD8+、CD8+T细胞差异无统计学意义(P>0.05),不孕症抑郁组与正常对照组和不孕非抑郁组相比外周血CD4+T细胞和CD4+/CD8+下降,CD8+T细胞升高,差异有统计学意义(P均<0.05),CD3+T差异无统计学意义(P>0.05)。结论女性不孕症患者人群中抑郁的发生率远高于正常人群;女性不孕伴发抑郁者可降低细胞免疫功能。
Objective To Explore the relationship between depression and the cellular immunity in Female infertility.Methods The situation of depression was evaluated by self-rating depression scale（SDS） in 214 female infertility patients.peripheral blood T cell subsets were determined by flow cytometry to analyze the relationship between psychological status and immunology in female infertility.Results SDS scores of female infertile patients were higher than those of the national norm.CD3 ＋ T cells,CD4 ＋ T cells and CD4 ＋/CD8 ＋,CD8 ＋ T cells showed no significant difference between infertile non-depressed group and the control group（P0.05）.Peripheral blood CD4 ＋ T cells and CD4 ＋/CD8 ＋ in infertile depression group were significantly lower than those in normal control group and infertile non-depressed group.Peripheral blood CD8 ＋ T cellsin infertile depression group were significantly higher than those in normal control group and infertile non-depressed group.Conclusion The incidence of depression in the female infertile patients is much higher than the normal population.The cellular immune function of female infertility with depression is lower than that of normal pregnant women and female infertility without depression.Depression may increase the infertility by affecting the immune balance in female infertility patients.
出处
《宁夏医科大学学报》
2011年第3期231-233,共3页
Journal of Ningxia Medical University
基金
宁夏高等学校科学技术研究项目(2009年)
关键词
女性不孕症
抑郁症
T淋巴细胞亚群
免疫调节
female infertility
depression
T lymphocyte subsets
cellular immunity
