摘要
目的：观察联合用药治疗类风湿关节炎以提高青藤碱疗效，减少不良反应。方法：联合用药组３５ 例，其中男性１０ 例，女性２５ 例；年龄３９ ａ ±ｓ ８ａ ； 病程５ ａ ±４ ａ 。青藤碱组２８ 例，其中男性８ 例，女性２０ 例；年龄３８ ａ ±９ ａ ；病程５ ａ ±３ ａ 。２ 组均服青藤碱片８０ ｍ ｇ ， ｐｏ ，ｔｉｄ ×６ ｍｏ 。联合用药组另加用氯喹０ ．２５ ｇ ， ｐｏ ，ｑｎ ×２ ｍ ｏ 后减为０ ．１２５ ｇ ， 共服６ ｍｏ ； 雷公藤多苷（ 甙） 片２０ ｍｇ ， ｐｏ ， ｂｉｄ ×６ｍｏ 。结果：联合用药组和青藤碱组临床缓显率（ 缓解率加显效率） 分别为７４ ％ 和２５ ％ （ Ｐ＜ ０ ．０１） 。不良反应发生率分别为１１ ％ 和３２ ％ （ Ｐ＜ ０ ．０１） 。结论：联合治疗方案治疗类风湿关节炎，比单用青藤碱疗效高，不良反应少。
AIM: To observe the efficacy of sinomenine in combination chloroquine and tripterygium wilfordii glycosides in treating rheumatoid arthritis. METHODS: Combined use group (M 10, F 25; age 39 a±s 8 a, course of disease 5 a±4 a) and sinomenine group (M 8, F 20; age 38 a±9 a, course of disease 5 a±3 a) were treated with sinomenine 80 mg, po, tid, for 6 mo. Combined use group was associated with chloroquine 0.25 g, po, qn, after 2 mo dose of chloroquine was reduced to 0.125 g, for 6 mo, tripterygium wilfordii glycosides 20 mg, po, bid, for 6 mo. RESULTS: In combined use group and sinomenine group, the remission and marked effective rates (remission plus marked effects rate were respectively 74% and 25%, P<0.01). The rates of adverse reaction were respectively 11% and 32%. The rates of adverse reaction of combined use group was decreased markedly. CONCLUSION: The combination drug therapy for treatment of rheumatoid arthritis in comparision with sinomenine singlely there is high efficacy and the lower rates of adverse reaction.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
1999年第4期215-217,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
类风湿性关节炎
青藤碱
氯喹
雷公藤
药物疗法
rheumatoid arthritis
sinomenine
chloroquine
Tripterygium wilfordii
glycosides
combination drug therapy
