摘要
目的 研究新型氮化硅陶瓷复合种植体周围骨界面的动态变化。方法 采用4只Beagle犬作实验动物,氮化硅复合羟基磷灰石种植体、单一氮化硅种植体为实验组,钛合金种植体及钛合金复合羟基磷灰石种植体为对照组。分期植入动物股骨内,取不同期骨标本制备磨片,用骨计量学方法分析比较不同种植体界面骨的生长代谢情况,从定量、动态的角度对其生物相容性给予评价。结果 1个月时氮化硅复合种植体—骨界面的矿化沉积速率等参数均高于对照组,单一氮化硅种植体在植入6个月后,其骨计量学参数与其他各组间差异无显著性。结论 氮化硅种植材料具有临床应用价值,采用骨计量学方法定量。
Objective To study the dynamic changes of bone interface with silicon nitride (Si 3N 4)composite implants.Methods 4 Beagle dogs were experimental animals,Si 3N 4 HA and pure Si 3N 4 implant were experimental group,and Ti and Ti HA were used as comparisons.They were implanted into dogs’ femurs by stages.Histomorphometry was used to analyse and compare bone growth metabolism of bone interface with implant as well as evaluation of biocompatibility from quantitative and dynamic aspects.Results Parameters expressing mineralization and speed of deposition at the Si 3N 4 HA bone interface were higher than comparisions’ at the first month. After 6 months, pure Si 3N 4’s bone histomorphometic parameters had no notable difference with others. Conclusion New implant material is useful to the clinic. The histomorphometry is of much value for the study of interface bone metabolism from quantitative and dynamic point of view.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1999年第4期223-225,共3页
Chinese Journal of Stomatology
