摘要
目的 研究大鼠脊髓水平 M受体拮抗剂阿托品、哌仑西平对α2 受体激动剂可乐定抗伤害效应的影响。方法 SD大鼠蛛网膜下腔埋入导管并长期留置。实验时分别将生理盐水、可乐定、阿托品、阿托品 +可乐定、哌仑西平、哌仑西平 +可乐定经导管注入蛛网膜下腔 ,以热水甩尾阈值为痛反应指标 ,观察注药前后的效果。结果 可乐定可产生量效、时效相关的抗伤害反应 ;注射阿托品后3 0～ 90分钟和注射哌仑西平后 60～ 15 0分钟使甩尾阈值缩短 ;预注阿托品和预注哌仑西平可部分拮抗可乐定所产生的抗伤害效应。结论 在脊髓水平 ,α2 受体与脊髓内 M受体相关。
Objective To study the influnce of intrathecal atropine and pirenzepine on the antinociceptive effect of intrathecal α 2 agonist clonidine in the spinal level of rat,and to investigate the influence of spinal M and M 1 receptor on α 2 agonist Methods Intrathecal catheter was implanted for a long period animal experiment The following drugs were administered into subarachnoid through intrathecal catheter:0 9% NaCl,clonidine,atropine,atropine combined with cloindine,pirenzepine,pirenzepine combined with clonidine The tail flick thresholds as the antinociceptive effect guideline were observed before and after administration of drugs Results Delayed tail flick threshold was related to dose and time of clonidine administration;shortened tail flick threshold was found 30 90min after atropine injection,60 150min after pirenzepine administration;delayed tail flick threshold of clondine were antagonized partly by atropine or pirenzepine pre administered Conclusion Both atropine and pirenzepine can partly block the antinociceptive effects,produced by clonidine in the spinal level,indicating that the antinociceptive effects of clonidine is related to M l receptor in spinal level.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
1999年第7期426-428,共3页
Chinese Journal of Anesthesiology
基金
中山医科大学科研基金
关键词
受体
肾上腺素能α2
毒蕈碱拮抗剂
脊髓注射
Receptors,adrenergic,alpha 2 Muscarinic antagonists Injections,spinal Analgesia
