摘要
本文应用兔疫组化方法研究慢性肝炎肝细胞坏死与乙型肝炎病毒(HBV)标志及T细胞亚群的关系,结果发现:e抗原阳性(eAg+)患者肝内HBsAg与HBcAg检出率明显高于e抗原阴性(eAg-)患者;在大多数膜HBsAg或浆膜型HBcAg表达部位中间或周围伴有肝细胞坏死,聚集在eAg+慢性活动型肝炎肝细胞坏死部位的单个核细胞大多为OKT^+_8细胞,OKT^+_4细胞少见,提示:eAg+的肝细胞破坏与HBV标志膜表达及OKT^+_8细胞浸润有一定关系。
To explore the role of HBV antigen expression and monocyte infiltrate in situ in chronic hepatitis,HBV markers and the composition and number of mo-nocytes in the liver of chronic hepatitis B were immunohistochemically located and identified,and correlated with hepatocyte necrosis It was found that hepatic necrosis frequently took place in the centre or boundary of membraneous HBsAg and/or HBcAg expression and the majority of monocytes accumulated jn the necrosis foci showed CD8+cell token in HBeAg-positive stage of chronic active hepatitis(CAH).On the other hand,with HBeAg converted into anti-HBe positive,HBV antigen expression significantly declined,and CD4+ cells remarkably increased as compared with HBeAg positive status.These findings suggest that there may be distinct pa-thogenesis of hepatic necrosis in different stages of chronic HBV infection.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1990年第1期39-42,共4页
Acta Universitatis Medicinae Tongji
基金
"七.五"期间国家重点科技攻关项目
关键词
乙型肝炎
乙肝病毒
T细胞亚群
HBV markers
T cell subsets
immunopathology
target antigens
hepatitis B
