摘要
目的：探讨Ｂｃｌ－２、Ｐ１７０ 在复发难治急性白血病表达的临床意义。方法：用ＡＢＣ免疫细胞化学方法检测７７ 例急性白血病Ｂｃｌ－２、Ｐ１７０ 的表达。结果：复发难治的急性白血病Ｂｃｌ－２、Ｐ１７０ 的表达显著高于初治者。Ｂｃｌ－２、Ｐ１７０ 高表达的急性白血病完全缓解率低，早期复发率高，预后差。Ｂｃｌ－２ 或Ｐ１７０ 高表达者，５０％ 为难治性白血病，二者同时高表达者均为难治性白血病。Ｂｃｌ－２ 与急性白血病预后的阳性符合率９０．９％ ，较Ｐ１７０ 略高。Ｂｃｌ－２ 与Ｐ１７０ 的表达呈轻度正相关（ ｒ ＝ ０．３８６， Ｐ ＜０．００１）。结论：Ｂｃｌ－２、Ｐ１７０ 的高表达是反映急性白血病复发、难治的重要指标。Ｂｃｌ－２ 的预测敏感性较高。不同的ＭＤＲ机制之间可能存在联系。
Objective:To investigate the clinical significance of Bcl 2 and P170 in relapsed refractoy acute leukemia.Method:The expression of Bcl 2 and P170 were detected by Avidin Biotin peroxidase immunocytochemistry technique in 77 cases of acute leukemia patients.Result:The expression of Bcl 2 and P170 were higher in patients with relapsed/refractory AL than that of patients with AL untreated.The low CR rate and high early recurrent rate were found in the patients with overexpression of Bcl 2 or P170.Half of the patients with high expression of Bcl 2 or P170 were refractory,and when the two markers were all overexpression,these patients were surely refractory.The coincident rate of Bcl 2 with the prognosis of AL was 90.9 %,which was little higher than that of P170.There were light positive correlation between Bcl 2 and P170 (r= 0.386 ,P< 0.001 ).Conclusion:The highexpression of Bcl 2 or P170 was one of the important indexes reflecting the recurrence or refraction of AL.Bcl 2 has more predictive sensitivity.There might be correlation among different MDR mechanisms.
出处
《临床血液学杂志》
CAS
1999年第4期161-163,共3页
Journal of Clinical Hematology
关键词
白血病
BEL-2
P170
MDR
治疗
急性
Leukemia Bcl 2 P170 MDRlone
biological characteristics
Heterogeneity
metastatic ability
