摘要
目的观察使用万古霉素静脉及鞘内联合用药治疗开颅手术后并发颅内感染的临床疗效与安全性。方法选择开颅手术后并发颅内感染患者42例,随机分为治疗组和对照组各21例。治疗组选用盐酸去甲万古霉素注射液1.0 g,静脉滴注,2次/d,同时结合10mg盐酸去甲万古霉素腰穿鞘内注射,1次/d;对照组选用盐酸去甲万古霉素注射液1.0 g,静脉滴注2,次/d。结果治疗组、对照组临床有效率分别为95.2%(20/21)、61.9%(13/21),差异有统计学意义(P<0.05);两组各有2例与万古霉素相关不良反应发生,治疗组未增加不良反应发生率。结论盐酸万古霉素静脉及鞘内联合用药治疗手术后颅内感染安全有效。
Objective To evaluate the clinical effect and safety of intravenous and intrathecal administration of vancomycin hydrochloride for the patients with postoperative intracranial infections.Methods 42 patients with postoperative intracranial infections were randomly divided into therapy group（n=21,vancomycin hydrochloride 1.0g,intravenous injection,Bid;10mg,intrathecal injection,qd） and control group（n=21,vancomycin hydrochloride 1.0g,intravenous injection,Bid）.Results The total clinical efficacy rate in therapy group and control group were 95.2%（20/21）and 61.9%（13/21）,respectively.There were statistic difference between two groups（P0.05）;2 cases in each group had vancomycin-related adverse reactions.The adverse reaction rate was not increased in therapy group.Conclusion Intravenous and intrathecal administration of vancomycin hydrochloride is an effective and safe method in treatment of patients with postoperative intracranial infections.
出处
《临床军医杂志》
CAS
2011年第2期269-271,共3页
Clinical Journal of Medical Officers
关键词
颅内感染
鞘内注射
万古霉素
intracranial infections
intrathecal injection
vancomycin
