摘要
目的:观察川芎嗪、丹参酮ⅡA、泛醌和艾地苯醌四个药物对小鼠学习记忆的影响。方法:采用小鼠水迷宫评价促智作用。结果:与东莨菪碱模型组相比,丹参酮ⅡA(20mg·kg^(-1),ig)到达平台的时间从(36±19)s缩短至(11±5)s,进入死角错误从(7±5)次减少至(1.5±1.3)次;泛醌(20mg·kg^(-1),ig)也能缩短时间从(37±18)s至(17±12)s和减少错误次数从8±5至2.1±2.7;艾地苯醌(120mg·kg^(-1),ig)只能显著缩短时间从(8±6)s至(3.4±2.9)s。川芎嗪不能缩短时间和减少错误。结论:丹参酮ⅡA、泛醌和艾地苯醌能不同程度地改善小鼠因东莨菪碱所致的记忆损害。
AIM: To observe the effects of four drugs, ligustrazine (Lig), tanshinone Ⅱ A (Tan), ubiquinone (Ubi) and idebenone (Ide), on learning and memory of mouse. METHODS: Mouse water maze was used to evaluate nootropic effect. RESULTS: In comparison with the defective model (only scopolamine 3 mg ·kg-1, Tan 20 mg·kg-1, ig) shortened the escape latency dramatically from (36 · 19) s to (11 · 5) s ( P < 0.01) and reduced errors from 7 · 5 to 1.5 · 1.3 ( P < 0.05). Ubi 20 mg·kg-1 ig decreased the escape latency from (37 ±18) s to (17 ± 12) s and errors from 8 ± 5 to 2.1±2.7 (P<0.01). Ide 120 mg·kg-1(ig) reduced the errors from 8±6 to 3.4±2.9 (P<0.05), but had no remarkable effect on the escape latency. Lig did not exhibit marked effect on the deficit. CONCLUSION: Tan, Ubi, and Ide improved scopolamine-caused spatial performance defects in mouse.
出处
《中国药理学报》
CSCD
1999年第11期987-990,共4页
Acta Pharmacologica Sinica
关键词
迷宫学习
川芎嗪
丹参酮ⅡA
艾地苯醌
药理
maze learning
ligustrazine
tanshinone Ⅱ A
ubiquinone
idebenone
scopolamine
pyrazines
benzoquinones
