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门冬胰岛素和短效胰岛素CSⅡ短期强化治疗对2型糖尿病疗效比较 被引量:1

Comparison of the efficacy between insulin aspart and prompt insulin with continuous subcutaneous insulin infnsion(CSⅡ) in type 2 diabetics
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摘要 目的:比较门冬胰岛素和短效胰岛素CSⅡ短期强化治疗对2型糖尿病的疗效。方法:对门冬胰岛素组例191(诺和锐组)与短效胰岛素组216例行CSⅡ短期强化治疗,比较其治疗前后FPG、平均PG、FC-P和2hC-P,及血糖达标时间和达标时胰岛素用量。结果:门冬胰岛素、短效胰岛素作为泵用胰岛素行CSⅡ治疗的疗效并无太大差异(P>0.05),均没有严重低血糖发生,且血糖达标时间也无显著性差异(P>0.05),而达标时的胰岛素用量门冬胰岛素要显著少于短效胰岛素(P<0.05)。结论:使用门冬胰岛素行CSⅡ治疗2型糖尿病效果良好,无不良作用,且较为经济,是临床值得推广的好方法。 Objective:To compare the efficacy and safety between insulin aspart and prompt insulin with continuous subcutaneous insulin infnsion(CSⅡ) in type 2 diabetics.Methods:191 and 216 patients were treated with insulin aspart and prompt insulin by CSII,respectively.To compare Pre-Tx and Post-Tx FPG,average PG,FC-P,2hC-P,glucose-targeted time and insulin dosage.Results:After the treatment,insulin aspart group was as effective as prompt insulin group in the parameters of the above glucose and C-peptide(all P0.05).The average duration of treatment and hypoglycemia incidence showed no obvious difference between two groups(P0.05) but the insulin does and cost of hospitalization were markedly decreased in insulin aspart group(P0.05).Conclusion:Insulin aspart with CSⅡ treatment for type 2 diabetes effect is effectively and more economical.
机构地区 解放军第
出处 《医学信息(中旬刊)》 2011年第4期1281-1282,共2页 Medical Information Operations Sciences Fascicule
关键词 持续皮下胰岛素注射 门冬胰岛素 短效胰岛素 2型糖尿病 Continuous subcutaneous insulin infnsion Insulin aspart Prompt insulin Type 2 diabetics
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  • 1McKeage K,Goa KL.Insulin glargine:a review of its therapeuticuse as a long-acting agent for the management of type 1 and 2 diabetes mellitus.Drugs,2001,61:1599-1624.
  • 2Hamann A,Matthaei S,Rosak C,et al.A randomized clinical trial comparing breakfast,dinner,or bed time administration of insulin glargine in patients with type 1 diabetes.Diabetes Care,2003,26:1738-1744.
  • 3Cao M, Lee S. A cross-sectional analysis of different basal rate requirements for individuals on CSII. Diabetes, 2002, 51(Suppl 2) :A467.
  • 4都健,潘晓黎.胰岛素泵的临床应用及评价[J].辽宁实用糖尿病杂志,2002,10(2):57-58. 被引量:38
  • 5翁建平,李延兵,许雯,陈小华,廖志红,姚斌,邓婉萍,欧香忠,胡国亮.短期持续胰岛素输注治疗对初诊2型糖尿病患者胰岛β细胞功能的影响[J].中国糖尿病杂志,2003,11(1):10-15. 被引量:780

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