摘要
通过调查、抽血检测男性20～65岁18000人,检出HBsAg+、AFP(-)、肝功能(ALT)基本正常的患者2065例,按地区随机分为补硒组1112例及对照组953例。补硒组每人每天服亚硒酸钠05mg1片,对照组则服安慰剂1片。通过服药前瞻观察2年,补硒组血硒显著升高,与对照组比较有明显差异(P<001);相应谷胱甘肽过氧化物酶随之升高,与对照组比较亦有显著差异(P<001);相反补硒组外周血淋巴细胞微核检出率显著低于对照组(P<001)。补硒组肝癌发病率170863/10万(19/1112),对照组430220/10万(41/953),有非常显著差异(P<001),进一步证实在肝癌高发区高危人群中,尤其是低硒地区,补硒可以预防肝癌,补硒方法简单,易于推广。
Adding selenium to prevent primary liver cancer is one of the projects during “the ninth five years”.Blood samples of 18000 male persons aged from 20 to 65 have been collected and tested in this study.It reveals that there are 2065 cases of HBsAg positive,AFP negative and normal liver function(with normal ALT values).According to their living areas,this screened population is divided randomly into two groups:1112 persons of adding selenium and 953 persons of controls.One tablet of 0 5 mg Na 2SeO 3 is given to each person of adding selenium group per day,and the same doses of placeboes for control group.With two years of drug administration and observation,the blood selenium concentration of adding selenium group is conspicuously improved with significant difference comparing with that of control group( P <0 01).The relative glutathione peroxides is also improved comparing with that of control group( P <0 01).On the contrary,the testing rate of micronucleus of adding selenium group in peri-blood lymphocytes is significantly lower than that of control group( P <0 01).The HCC incidence of adding selenium group and control group are respectively 1708 63/100000(19/1112) and 4302 20/100000(41/953).There is conspicuous difference between them( P <0 01).It further confirms that adding selenium in high dangerous population in high HCC prevalent raea,especially in lower selenium area,can prevent liver cancer.It’s simple to add selenium and easy to popularize.
出处
《广东微量元素科学》
CAS
1999年第10期23-26,共4页
Trace Elements Science
基金
国家"九五"攻关项目
