摘要
目的观察甲地孕酮(MA)对EP方案治疗小细胞肺癌患者生活质量的影响。方法 67例小细胞肺癌患者随机分成治疗组和对照组,所有患者均给予EP方案化疗,其中治疗组同时给予MA口服治疗,观察并记录患者治疗前后KPS评分、食欲、体重及睡眠变化情况。结果治疗组化疗后KPS评分升高4,而对照组降低了10,两组间KPS评分在化疗后比较有显著性差异(P<0.05);治疗组化疗后食欲增加者占82.3%(28/34),对照组食欲增加者占6.1%(2/33),两组间比较有显著性差异(P<0.05);治疗组化疗后体重增加者占70.6%(24/34),对照组体重增加者占9.1%(3/33),两组间比较有显著性差异(P<0.05);治疗组化疗后睡眠好者占50%(17/34),对照组睡眠好者占18.2%(6/33),两组间比较有显著性差异(P<0.05)。结论甲地孕酮能明显提高EP方案化疗小细胞肺癌患者的生活质量,值得临床推广应用。
Objective To investigate the effect of megestrol acetate（MA） to improve the quality of life in patients with small cell lung cancer treated by EP regimen. Methods 67 cases with small cell lung cancer were randomly divided into two groups： 34 cases in treatment group（MA＋EP） and 33 cases in control group（EP）.the change of KPS,appetite,body weight and sleep in each group after treatment were observed. Results In KPS there was no significant difference between two groups before chemotherapy,while significant difference were shown with 4 rising in treatment group and-10 increased in control group after the treatment.Significant statistical difference（P0.05） was shown with 14.6 more in the former than the latter in KPS.Obvious improvements（P0.05） were also shown in the member of appetite improved in 82.3%（28/34）,body weight increased in 70.6%（24/34） and better sleep in 50%（17/34） in treatment group,compared with 6.1%（2/33）,9.1%（3/33）,and 18.2%（6/33） in control group after chemotherapy in statistics. Conclusion Megestrol acetate can significantly improve the quality of life in patients with small cell lung cancer treated by EP regimen.
出处
《河南科技大学学报（医学版）》
2011年第1期42-44,共3页
Journal of Henan University of Science & Technology:Medical Science
关键词
甲地孕酮
化疗
小细胞肺癌
生活质量
megestrol acetate
chemotherapy
small cell lung cancer
quality of life
