摘要
目的 探讨增强光动力学疗法(PDT) 治疗恶性肿瘤疗效的有效途径。方法 80 只昆明种小白鼠于皮下接种小鼠肝癌细胞,待肿瘤长到6 ～8 mm ,随机分为先化疗后PDT、先PDT 后化疗、单纯PDT、单纯化疗和空白对照共5 组,每组16 只。化疗方法为腹腔注射5氟尿嘧啶75 μg/g ;PDT 方法为经尾静脉注射血卟啉单醚20μg/g 后3 h 以能量密度135 J/cm2 的铜蒸气激光照射肿瘤部位。结果 采用不同治疗措施的4 组小鼠瘤体缩小,而空白对照组小鼠瘤体迅速增大,各治疗组与空白对照组比较,差异均有显著意义( P< 0-05) 。各治疗组中以先化疗后PDT 组瘤体缩小尤为显著,与其他3 组比较,差异有显著意义( P< 0 .05) 。结论 PDT 和化疗均有抑瘤效应,两种方法联合运用可提高对小鼠移植瘤的疗效,而先化疗后PDT 治疗的疗效优于先PDT 后化疗。
Objective To explore the possibility ofphotodynamictherapy (PDT) combined with chemotherapy (CMT)toimprovethe effectiveness ofcan certreatment. Methods 80 mice with subcutaneously transplanted hepatoma that grew to 6 8 m m were randomly divided into 5 groups: CMT PDT; PDT CMT;PDT;CMTand control. Each group had 16 mice.CMT:5 Fu (75 μg/g) wasinjectedi.p .PDT:Hematoporphyrin monomethyl ether (HMME) (20 μg/g) wasinjectedi.v.and followed bylaserirradiation (wavelength 510 .6 nm ,power density 135 J/cm2) 3 hourslater. Results The size ofthetumorsin 4 groups with differenttreatmentreduced rapidly andthetumorsin controlgroup enlargedrapidly .Astatis tically significant difference wasfound between the experimental groups and the control group ( P< 0 .05) .Inthe experimental groups,thein hibition rate of CMT PDTgroup was significantly higherthan thatofother3 groups.The differences were statistically significant( P< 0 .05) . Conclusions PDTand CMThaveinhibition effect ontumors.The resutlsrevealed that PDTcombined with CMTmight excert better destructive effecton tumors ,and the destructive effect of CMT PDTwas significantly higherthan thatof PDT CMT.
出处
《中国激光医学杂志》
CAS
CSCD
1999年第3期148-150,共3页
Chinese Journal of Laser Medicine & Surgery
关键词
光化学疗法
药物疗法
肿瘤
Photochemotherapy
Drug therapy
Neoplasms
