摘要
目的观察糖尿病患者血清胱抑素C(CysC)水平的变化,证实其在早期糖尿病肾病中的诊断价值。方法用免疫透射比浊法测定163例糖尿病患者和48例健康者的血清CysC水平,同时分别以脲酶紫外速率法和碱性苦味酸法测定各例的血清尿素及肌酐。结果尿微量清蛋白(mAlb)正常组与健康对照组的CysC结果比较差异无统计学意义(P>0.05),尿mAlb升高组CysC水平显著高于尿mAlb正常组和健康对照组(P<0.05),尿蛋白阳性组CysC水平显著高于尿mAlb升高组(P<0.01)。除尿蛋白阳性组与另外3组的尿素、肌酐水平比较差异有统计学意义(P<0.01)以外,其他3组之间的差异均无统计学意义(P>0.05)。结论 CysC比血清尿素、肌酐能更敏感、更特异地反映肾小球滤过率,对糖尿病肾病的早期诊断有重要价值。
Objective To observe the serum cystatln C （Cys C） levels in diabetic patients,so as to confirm the diagnosis value of Cys C in the early diabetic nephropathy. Methods The measurement of immune transmission nephelometry was used to measure the level of Cys C in 163 case of diabetic patients and 48 cases of healthy human as control group. Urease UV rate method and alka line picric acid method were used to measure the level of the urea and creatinine in each case. Results There was no significant difference of serum Cys C level between the normal urinary micro albumin （mAlb） group and the control group（P〉0.05）. The Cys C level of the increased urinary mAlb group was significantly higher than the normal urinary mAlb group and the control group （P 〈0.05）. The Cys C level of the urinary protein positive gro.up was significantly higher than the increased urinary mAlb group （P〈 0.01）. Only the urea and creatinine level of urinary protein positive group was significantly higher than the other three groups （P〈 0.01）. Conclusion Serum cystatin C is more sensitive and specific than urea and creatinine to evaluate the glomerular filtration rate. It was important to diagnose early diabetic nephropathy.
出处
《国际检验医学杂志》
CAS
2011年第4期453-454,共2页
International Journal of Laboratory Medicine
关键词
糖尿病肾病
早期诊断
胱抑素C
diabetic nephropathies
early diagonosis
cystatin C
