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胸腺移植治疗神经系统免疫性疾病的研究 被引量:3

Thymic transplantation for treatment of immune diseases in nervous system.
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摘要 目的 报告30 例神经系统免疫性疾病患者接受胚胎胸腺移植治疗。方法 胸腺取自于水囊引产死胎, 制成组织匀浆植入腹直肌或股前肌群内。结果 移植后半年内, 患者临床症状明显改善, 免疫状态调节至正常, 总的疗效达86 .7 % 。结论 胸腺移植作为一种治疗神经系统免疫性疾病的新方法值得进一步探讨研究。 Objective Thirty cases of immune diseases (including multiple sclerosis, polymyositis, myasthenia gravis,gullian barre syndrome) in nervous system underwent the treatment of fetal thymic transplantation.Methods The thymus was harvested from abortive fetus of 20 to 30 pregnant weeks in health women by legal water capsule inducing labour. The tissue homogenate was prepared and implanted into the abdominal muscles or thigh muscles within 1?h. Result Six months after transplantation, the clinical symptoms were significantly improved, and immune status was regulated. The overall effective rate was 86.7% .Conclusion Thymic transplantation as a new method for treating immune diseases in nervous system is required to be further studied.
出处 《中华器官移植杂志》 CAS CSCD 1999年第4期240-241,共2页 Chinese Journal of Organ Transplantation
关键词 胸腺移植 免疫性疾病 治疗 Thymic/transplantation Immune disease
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参考文献2

  • 1刘敦贵.胚胎胸移植治疗晚期肝癌的研究[J].中华器官移植杂志,1990,11:16-18.
  • 2刘敦贵,中华器官移植杂志,1990年,11卷,16页

同被引文献24

  • 1王廷端,冯仲珉.胚胎胸腺及脾细胞悬液联合静脉输注治疗晚期恶性肿瘤四例报告[J].中华器官移植杂志,1993,14(2):90-91. 被引量:1
  • 2李世德,赵劲民,苏方荣,杨渊.胎儿胸腺移植治疗晚期恶性骨肿瘤[J].中华器官移植杂志,1995,16(4):178-178. 被引量:2
  • 3Hong R,Santosham M,Schulte-Wissermann H,et al.Reconstitution of B and T lymphocyte function in severe combined immunodeficiency disease after transplantation with thymic epithelium.Lancet 1976;2:1270
  • 4Dupuy JM,Gilmore N,Goldman H,et al.Thymic epithelial cell transplantation in patients with acquired immunodeficiency syndrome.Evidence for infection by HIV-Ⅰ of newly differentiated T cells at the site of transplantation.Thymus1991;17:205
  • 5Danner SA,Schuurman HJ,Lange JMA,et al.Implantation of cultured thymic fragments in patients with acquired immuno-deficiency syndrome.Arch Int Med 1986;146:1133
  • 6Ortak T,Oke R,Unsal M,et al.A Model of Vascular thymus transplantation in athymic rats.Transplant Proc 2001;33(1-2):372-4
  • 7Lambrigts D,Menard MT,Alexandre GPJ,et al.CREATION OF THE "THYMOHEART" ALLOGRAFT:Implantation of Autologous Thymus into the Heart Prior to Procurement.Transplantation 1998;66(6):810-4
  • 8Yamada K,Shimizu A,Ierino FL,et al.Thymic transplantation in miniature swine :I.developmentand function of the "thymokidney".Transplantation 1999;68(11):1684-92
  • 9Nishimura Y,Antoniou E,DeRoover A,et al.Whole organ vascularized thymus allografting effectively modulates cardiac rejection.Transplant Proc 1996;28:1281
  • 10Ohuchi H,Madsen JC,Neragi-Miandoab S,et al.A novel technique for en bloc,vascularized,composite thymic,and cardiac co-transplantation.Transplantation 2002; 74(3):403-5

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