摘要
目的：观察葛根素联合依帕司他治疗2型糖尿病周围神经病变的临床疗效。方法：将50例患者随机分为2组，治疗组25例采用葛根素联合依帕司他治疗，对照组25例采用复方丹参注射液联合甲钴胺治疗，疗程2周，比较电生理学指标和有效率。结果：通过葛根素联合依帕司他治疗，正中神经、腓总神经的运动神经传导速度（MNCV）与感觉神经传导速度（SNCV）显著改善，与治疗前比较有显著差异。治疗组与对照组比较，对MNCV和SNCV的改善更具有统计学意义的提高。治疗组的显效率高于对照组，组间差异具有统计学意义。结论：葛根素联合依帕司他是一种治疗2型糖尿病周围神经病变的有效方法，疗效优于复方丹参注射液联合甲钴胺。
Objectives： To assess the effect of puerar/n combined with epalrestat in the treatment of type 2 diabetic peripheral neuropathy. Methods： 50 patients with DPN were randomly assigned into puerarin plus epalrestat treatment group and salvia plus mecobalamin control group. The treatment duration was two weeks. Electrophysiological measures and symptoms Were evaluated. Results： The motor nerve conduction velocity （MNCV） and sensory nerve conduction velocity （SNCV） in median and peroneal nerves were signifi- candy improved in both two groups. The improvement on MNCV and SNCV in treatment group was significantly better than the control group after treatment. The symptoms improvement in treatment group was significantly pronounced than in controls. Conclusion： Puerarin p/us epalrestat was an effective treatment approach for the management of type 2 diabetic peripheral neuropathy.
