摘要
目的 探讨磷灼伤中毒主要物质及机理。方法 以黄磷灼伤模型和磷酸热液热力致创面后磷酸吸收中毒模型， 在创面残留总磷量相近的情况下， 对黄磷与磷酸灼伤两组实验动物的中毒及死亡进行比较。结果 磷酸烫伤与黄磷灼伤均表现为血磷水平升高、血总钙正常而血游离钙下降， 细胞游离钙降低的同时血小板聚集功能抑制、主要脏器病理损害及７ 天死亡率（６０ ％ ） 均相同。结论 磷燃烧后经创面吸收中毒是一种特殊的中毒形式。磷在燃烧破坏皮肤屏障过程中形成的磷酸已经足以引起所有的磷灼伤中毒表现， 磷酸与黄磷灼伤致死性相同表明磷酸在磷灼伤中毒中起主要作用。
Objective To investigate the main toxicants and poisoning mechanism in phosphor burns(PB).Methods A scald model with hot phosphoric acid(PA)was made and compared with PB which had equal total contents of phosphorus within wound. Results Both PA and PB caused increased content of plasma phosphorus,decreased levels of blood and intracellular free calcium companied with reduced platelet aggregation rate when total plasma calcium was normal,the similar serious damages in visceral organs and mortalities(about 60%)within 7 days after burns.Conclusion Systemic poisoning after PB had its features.The amounts of phosphoric acid produced and absorbed from the injured skin surface could induce the systemic poisoning in phosphor burns,especially there were the similar mortalities in the two groups.It suggests phosphoric acid might be the main toxicant.
出处
《中国工业医学杂志》
CAS
1999年第5期265-267,共3页
Chinese Journal of Industrial Medicine
基金
全军医药科研基金
关键词
磷灼伤
磷酸
中毒
游离钙
中毒机理
Phosphor burns
Phosphoric acid
Poisoning
Free calcium
