摘要
目的：观察抗肿瘤药去甲长春花碱（ＮＶＢ） 加顺铂联合治疗晚期非小细胞肺癌疗效。方法：共收治晚期非小细胞肺癌３０ 例，均为Ⅲｂ ～Ⅳ。女性１０ 例，男性２０ 例。初治１６ 例，复治１４ 例。结果：部分缓解（ＰＲ）１３ 例，稳定（ＳＤ） １０ 例， 进展（ＰＤ） ７ 例， 总有效率４３ ％ ， 中位生存时间８ 个月。骨髓抑制为剂量限制性毒性， 其中Ⅱ～Ⅲ度为５２ ％ ，局部静脉炎２３ ％ 。结论：ＮＶＢ＋ ＰＤＤ 联合治疗晚期非小细胞肺癌是一个毒性中等，疗效较好的一线方案。
Objective: To evaluate the efficacy and toxicity of NC regimen (Navelbine 30mg/M ,iv, d1,8; and Cisplatin 30mg/m2 iv, d1, 2, 3; repeated every 21 days) in the treatment of non-small cell lung cancer (NSCLC). From 1994 to 1998, 30 patients with advanced NSCLC (Ⅲb,Ⅳ) were treated. Female 10, male 20,age ranged from 37～70 years with a median age of 60 years. Methods: Adenocarcinoma 23 ,squamous cell carcinoma 6, large cell 1. Sixteen patients had no prior chemotherapy and 14 were previously treated. The total number of cycles for 30 patients were 94 with the median being 3.5 cycles. Results: Partial response 13, stable of disease 10, and 7 progressed. Overall response rate was 43%, the median survival were 8 months. The dose limiting toxicity was neutropenia with grades Ⅱ～Ⅲin 52%(16/30), grade IV in 0%. Phlebitis was noted in 23%(7/30), peripheral neurotoxicity in 17%(5/30). During the same period of time, we treated 43 cases of advanced NSCLC parallelly with PVM regimen (DDP, VDS, MMC), the response rate was only 20%(9/43). Conclusion: NVB plus DDP regimen was impressively effective in NSCLC in this part of China. The toxicity was mild to moderate and reversible.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1999年第10期765-766,共2页
Chinese Journal of Clinical Oncology
关键词
非小细胞肺癌
去甲长春花碱
顺铂
治疗
Non-small cell lung cancer Chemotherapy Navelbin Cisplatin
