摘要
目的从痰及体液等临床标本中分离培养出分枝杆菌并进行体外药物敏感性分析,为临床合理选用抗菌药物提供依据。方法采用绝对浓度间接法试验对251份培养阳性标本进行4种抗结核药物(INH、RFP、EMB、SM)的耐药性测定。结果总耐药率为60.96%(153),初治耐药率为45.10%(69),初治耐多药率为30.07%(46),复治耐药率为85.71%(84),复治耐多药率为56.12%(55)。耐药顺序为RFP﹥INH﹥SM﹥EMB,耐药率分别为49.80%、47.41%、25.10%、18.73%。结论本地结核菌耐药情况严重,因此应加强抗结核药物的耐药性监测,根据药敏结果选择有效化疗方案,彻底治疗结核病人。
Objective To isolate the drug-resistant Mycobacteria from clinical samples and investigate their level of antibiotic resistance.Method 251 isolates were tested for their resistance against isoniazid（INH）,rifampicin（RFP）,ethambutol（EMB） and streptomycin（SM）.Results The rate of total drug resistance,initial drug resistance,initial multi-drug resistance,acquired drug resistance and acquired multi-drug resistance was 60.96%（153）,45.10%（69）,30.07%（46）,85.71%（84）,and 56.12%（55）,respectively.The rate of resistance against INH,RFP,SM,and EMB was 49.8%,47.41%,25.1% and 18.73%,respectively.Conclusion The rate of drug resistance in this area is serious.Strengthening of the drug resistant monitoring program and to select medicine based on drug sensitivity test is important in the disease management.
出处
《热带医学杂志》
CAS
2010年第12期1418-1420,共3页
Journal of Tropical Medicine
关键词
分枝杆菌
培养
耐药性
药物敏感性
Mycobacterium
culture
antibiotic resistance
drug sensitivity
