摘要
目的探讨松果体内毛细血管和松果体细胞分泌颗粒的超微结构特征及其意义。方法采用常规生物电镜样品制备技术，对成年日本猴松果体进行了透射电镜观察。结果猴松果体血管及毛细血管只存在于被囊和小叶间隔的结缔组织内，松果体实质小叶内并无血管。毛细血管内皮为窗孔（５０ｎｍ）型，外有基膜与血管周围结缔组织分隔。松果体实质小叶主要由松果体细胞和少数胶质细胞组成。松果体细胞的突起终止于血管周隙内；分泌颗粒大量存在于松果体细胞突起的杵状终末或偶尔见于结缔组织间隙内；分泌颗粒为直径２００～５００ｎｍ的大型膜包密芯颗粒。结论这些超微结构特征提示：松果体细胞分泌颗粒的外排形式可能为整体释放而非胞吐分泌；分泌颗粒内的物质更象神经多肽而非生物源胺；松果体分泌物更易经组织信息通道释放入脑脊液而非透过毛细血管壁进入血液。
ObjectiveFor exploring the ultrastructural feature and its significance of the blood capillary and the pinealocytic secretory granules in the pineal body. MethodsWith technology for preparing biologic electron microscopic specimens, the pineal bodies of adult Japanese monkey were observed by transmission electron microscope (TEM). ResultsThe blood vessels and capillaries in monkey pineal body existed only in the connective tissue of capsule and interlobular septum, those did not in the pineal parenchymal lobules. The endothelium of the blood capillary belonged to the fenestrated (50 nm) type, separated from the perivascular connective tissue by basement membrane. The pineal paraenchymal lobules were composed of many pinealocytes and a few glial cells. The pinealocytic processes terminated in the perivascular connective tissue space. The secretory granules existed more in the pinealocytic pestle endings and less in the connective tissue space. The secretory granules were some 200～500 nm large type dense core granules. ConclusionThese ultrastructural features indicate: The excretory formation of pineal secretory granules can be whole releasing rather than exocytosis; The substance in the secretory granules like rather neuropolypeptide than biogenic amine; The pineal secretions be released rather easily into cerebrospinal fluid by tissue channel, and than into blood fluid by wall of capillaries.
出处
《河北医科大学学报》
CAS
1999年第5期260-262,共3页
Journal of Hebei Medical University
关键词
松果体
毛细血管
超微结构
分泌颗粒
猴
pineal body
blood capillary/ultrastructure
secretory granule/ultrastructure
ultrastructure/TEM
monkeys
