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核内不均一核糖核蛋白A2/B1研究进展 被引量：3

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摘要 目前肺癌发病率居高不下，绝大多数肺癌早期表现无特征性，明确诊断一般已属晚期，治疗亦受限制，故5年生存率〈15％，为降低癌症死亡率，提高早期检测率，核内不均一核糖核蛋白A2／B1（heterogeneous nuclear ribonucleoprotein A2/BI, hnRNPA2/B1, hnRNPA2/B1 ）研究作为新的早期标记物，在临床表现之前，运用痰脱落细胞学预测肺癌可提高至1年，下面对近期研究进展做一综述。
作者 韩军 陆友金
机构地区 安徽医科大学第二附属医院呼吸内科
出处 《临床肺科杂志》 2011年第5期755-756,共2页 Journal of Clinical Pulmonary Medicine
关键词 核内不均一核糖核蛋白A2/B1 HNRNPA2/B1 早期表现 痰脱落细胞学 5年生存率 癌症死亡率 癌发病率 临床表现
分类号 R734.2 [医药卫生—肿瘤]
  • 相关文献

参考文献17

  • 1Kosturko LD, Maggipinto M J, Korza G, et al. Heterogeneous nuclear ribonucleoprotein(hnRNP) E1 binds to hnRNP A2 and inhibits translation of A2 response element mRNAs[J]. Mol Biol Ce11,2006 Aug;17(8) :3521 -33.
  • 2He Y, Rothnagel JA,Epis MR, et al. Downstream targets of heteroge- neous nuclear ribonucleoprotein A2 mediate ceil proliferation [ J ]. Mol Carcinog,2009 Feb ;48 ( 2 ) : 167 - 79.
  • 3Eddy J, Maizels N. Conserved elements with potential to form poly- morphic G-quadruplex structures in the first intron of human genes[J]. Nucleic Acids Res, 2008 Mar;36(4) :1321 -33.
  • 4Vera J,Jaumot M,Estanyol JM, et al. Heterogeneous nuclear ribo- nucleoprotein A2 is SET-binding protein and a PP2A inhibitor[J]. Oncogene ,2006 Jan 12 ;25 ( 2 ) :260 - 70.
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  • 7Martinez-Contreras R, Cloutier P, Shkreta L, et al. hnRNP proteins and splicing control[ Jl. Adv Exp Med Biol 2007, vol. 623 ,pp. 123 - 147.
  • 8Iijima M, Suzuki M, Tanabe A, et al. Two motifs essential for nucle- ar import of the hnRNP AI nucleocytoplasmic shuttling sequence M9 core[J]. FEBS Left. 2006 Feb 20;580(5) :1365 -70.
  • 9Pan H,Luo C,Li R,et al. CyclophilinA is required for CXCR4-me- diated nuclear export of heterogeneous nuclear ribonucleoprotein A2, activation and nuclear translocation of ERK1/2, and chemotactic cell migration[ J ]. J B iol C hem ,2008 Jan 4 ;283 (1):623 -37.
  • 10Kelland L. Targeting the limitless rephcative potential of cancer: The telomerase/telomere pathway[ J]. Ctin Cancer Res,2007 Sep 1 ;13 (17) :4960 -3.

二级参考文献8

  • 1王敬慧,张树才,刘志东,陈效友,李传友,韩毅马.肺癌患者外周血癌胚抗原、细胞角蛋白19 mRNA表达水平与肿瘤分期、近期疗效及预后的关系[J].中华结核和呼吸杂志,2005,28(11):773-776. 被引量：8
  • 2Qiao YL,Tockman MS,Li L,et al.A case cohort study of an early biomarker of lung cancer ina screening cohort of Yunnan tin miners in China[J].Cancer Epidemiol Biomarkers Prev,1997,6(11):893-900.
  • 3Burchill S,Bradbury M,Pittman K,et al.Detection of epithelial cancer cell in peripheral blood by reverse transcriptase-polymerase chain traction[J].Br J Cancer,2005,71(1):278-281.
  • 4Tockman MS,Gupta PK,Myers JD,et al.Sensitive and specific monoclonal antibody recognition of human lung cancer antigen on preserved sputum cells:a new approach to early lung cancer detection[J].J Clin Oncol,1998,6(11):1685-1693.
  • 5Zhou J,Mulshine JL,Unsworth,et al.Purification and characterization of a protein that permits early detection of lung cancer[J].J Biol Chem,2006,271(18):10760-10766.
  • 6Tockman MS,Mulshine JL,Piantadosi S,et al.Prospective detection of preclinical lung cancer:results from two studies of heterogeneous nuclear ribonucleoprotein A2/B1 overexpression[J].Clin Cancer Res,1997,3(12 Pt 1):2237-2246.
  • 7Fleischhacker M,Beinert T,Ermitsh M.Detection of amplifiable messenger RNA in the serum of patients with lung cancer[J].Ann NY Acad Sci,2001,945:179-188.
  • 8卢兆桐,付强,耿明,丁吉元,寇仁业,邹志强.异质性细胞核核糖蛋白A2/B1在非小细胞肺癌的表达研究[J].实用医药杂志,2003,20(3):161-163. 被引量：7

共引文献8

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二级引证文献14

临床肺科杂志
2011年 第5期

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