摘要
目的探讨99mTc-奥曲肽眼眶显像在判断甲状腺相关性眼病(TAO)活动性中的作用。方法 81例TAO患者(151个眼眶)和10例正常对照者(20个眼眶)均行99mTc-奥曲肽眼眶显像,并采用勾画感兴趣区技术计算眼眶与枕部颅骨的奥曲肽摄取比值(O/OCC)。结果 TAO活动组O/OCC比值(1.78±0.44)显著高于TAO非活动组(1.06±0.17)及正常对照组(1.09±0.09),P均<0.001,而TAO非活动组O/OCC比值(1.06±0.17)与正常对照组(1.09±0.09)比较无显著性差异(P>0.05)。所有TAO患者的O/OCC比值与其CAS评分具有很好的相关性(γ=0.899,P<0.001),根据O/OCC比值绘制ROC曲线,曲线下面积为0.979,当O/OCC比值取1.34时,显像敏感性88.3%,特异性94.6%。结论 99mTc-奥曲肽眼眶显像可帮助客观判断TAO的活动性,为临床治疗方案的选择提供依据。
Objective To evaluate the value of 99mTc-octreotide orbital scintigraphy in assessing the activity of thyroid associated ophthalmopathy.Methods 99mTc-octreotide orbital scintigraphy was performed in 81 patients with TAO （151 orbits） and 10 control subjects（20 orbits）.The scans were analyzed by a region of interest technique.An uptake ratio between the orbits and the occipital skull （O/OCC） was determined.Results The O/OCC ratio of the active group（1.78±0.44） was higher significantly than that of the inactive group （1.06±0.17） and the control group （1.09±0.09）,but no significant difference was found between the inactive group and the control group （P0.05）.A statistically significant correlation was found inthe O/OCC ratio versus CAS（γ=0.899,P0.001）.The area under the ROC curve for the O/OCC ratio was 0.979,a threshold value of 1.34 for the O/OCC ratio was presented with a sensitivity of 88.3% and a specificity of 94.6%.Conclusion 99mTc-octreotide orbital scintigraphy may be an objective tool in assessing the activity of TAO and may provide a guide to therapeutic strategy.
出处
《北京医学》
CAS
2011年第4期292-294,共3页
Beijing Medical Journal
