摘要
目的分析类风湿关节炎(RA)患者脂蛋白(a)水平及其与炎症的关系,探讨Lp(a)在RA患者心血管病发生中的意义。方法选择RA患者52例,正常对照40例,对受检者血脂、Lp(a)及炎症指标进行检测。结果活动性RA患者组Lp(a)水平为(289.1±96.6)mg/L,非活动性组Lp(a)水平为(176.8±78.0)mg/L,对照组为(172.6±63.1)mg/L;活动性RA组明显高于非活动性组和对照组;非活动组和对照组间无明显变化。血沉、C反应蛋白均分别与Lp(a)呈正相关。结论活动性RA患者Lp(a)发生显著变化,炎症反应对Lp(a)代谢具有调节作用,Lp(a)是急性时相反应蛋白之一,可能参与动脉粥样硬化的发生和发展。
Objective Rheumatoid arthritis（RA） patients with lipoprotein（a） the relationship between levels and inflammation,of Lp（a） the occurrence of cardiovascular disease in patients with RA significance.Methods 52 patients with RA,40 cases of normal controls were selected.Serum lipids of subjects,Lp（a） and inflammatory markers were detected.Results Active RA patients＇ Lp（a） level was 289.1 96.6 mg / L,non-active group＇s Lp（a） level was 176.8 78.0 mg / L,control group was 172.6 63.1 mg / L;active RA were significantly higher than that of inactive group and control group;non-active group and the control group did not change.ESR,C-reactive protein were both Lp（a） positive correlation.Conclusion Patients with active RA Lp（a） a significant change,inflammation of Lp（a） metabolism in a regulatory role,Lp（a） is one of acute phase protein,may be involved in the occurrence of atherosclerosis and development.
出处
《安徽医学》
2011年第3期344-345,共2页
Anhui Medical Journal
