摘要
性激素与心血管疾病密切相关。无论男女,雄激素均随年龄增长而下降,且与动脉粥样硬化和冠心病呈负相关。雄激素替代治疗可以改善血脂、血管内皮功能,舒张冠状动脉,缓解心绞痛症状。雌激素通过多个途径对心血管疾病产生影响,绝经后女性心血管事件的发生率迅速升高。雌、孕激素替代治疗(HRT)对心血管疾病的益处与风险存在争议,目前尚无指征采用HRT对绝经期妇女进行心血管疾病的一级或二级预防;对用于缓解更年期症状和防治绝经后骨质疏松症,则需权衡利弊,结合患者具体情况进行个体化治疗。
Sex hormones are closely linked to cardiovascular diseases. In the both genders, the level of an- drogen decreases along with advancing age, and is negatively associated with atherosclerosis （AS） and coronary heart disease. Androgen replacement therapy can improve blood lipids, vascular endothelial function, diastolic coro- nary arteries, and angina symptoms. Estrogen has a role in cardiovascular diseases via a variety of pathways, which may explain the rapid increase in cardiovascular events among postmenopansal women. There are still some de- bates over the benefits and risks of estrogen and progesterone replacement therapy （HRT） in treatment of cardio- vascular diseases. At present, there is evidence supporting the use of HRT in primary or secondary prevention of cardiovascular diseases among postmenopausal women. HRT for relief of menopausal symptoms and prevention of postmenopausal osteoporosis should be given only after the advantages and disadvantages have been weighed, and meanwhile in a personalized protocol.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2011年第4期266-268,共3页
Chinese Journal of Practical Internal Medicine
关键词
雄激素
雌激素
孕激素
心血管疾病
androgen
estrogen
progesterone
cardiovascular disease
