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液基薄层细胞学检测子宫颈病变4234例临床病理分析 被引量:2

Clinicopathological study of thinprep cytologic test on 4234 patients with cervical lesion
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摘要 目的 评价液基薄层细胞学检测(TCT)在子宫颈病变筛查中的意义。方法采用TCT系统采集子宫颈细胞学标本4234例,按照TBS系统(theBesthesdasystem)进行判读。对细胞学筛查为异常的272例[意义不明确的非典型性鳞状细胞(ASC—US)或以上病变]进行阴道镜下活组织病理检查。结果TCT与阴道镜下活组织病理检查结果符合率为低度鳞状上皮内病变(LSIL)85.71%(12/14)、高度鳞状上皮内病变(HSIL)100%(20/20)、鳞状细胞癌(SCC)75.00%(3/4)、腺癌(AC)100%(2/2)。TCT诊断不除外高级别鳞状上皮内病变的非典型性鳞状细胞(ASC—H)以上病变的阳性率为23.16%(63/272),活检病理组织学诊断子宫颈上皮内瘤样低度病变(CINI)以上病变的阳性率为24.26%(66/272),二者比较差异无统计学意义(X2=0.868,P=0.581)。结论TCT与活组织病理检查诊断有较高的符合率,二者结合能大大提高对子宫颈的高度病变和子宫颈癌的检出率,减少漏诊。TCT可作为子宫颈癌及癌前病变筛查的一种高效、便捷的方法。 Objective To estimate the clinical value of thinprep cytologic test (TCT) in screening cervical lesion. Methods 4234 TCT samples were interpreted according to the Besthesda System (TBS), 272 positive cases (ASC-US or above) were taken colposcopie examination and biopsy. Results The coincidence of the results between TCT and biopsy in low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), squamous cell carcinoma (SCC), adenocarcinoma (AC) were 85.71% (12/14), 100 % (20/20), 75 % (3/4) and 100 % (2/2), respectively. The positive rates of over ASC-H by TCT and of over CIN I by biopsy were 23.16 % (63/272) and 24.26 % (66/272), respectively. There is no difference between two positive rates (X2 = 0.868, P = 0.581). Conclusion TCT and histopathological diagnosis had a high coincidence, a combination of both can greatly enhance HSIL and cervical cancer and reduce the incidence of missed diagnosis. TCT would be a rapid and convenient method for screening cervical cancer.
出处 《肿瘤研究与临床》 CAS 2011年第3期176-178,共3页 Cancer Research and Clinic
关键词 子宫颈肿瘤 组织细胞学制备技术 诊断 Uterine cervical neoplasms Histocytological preparation techniques Diagnosis
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参考文献6

  • 1Solomon D,Davey D,Kurman R,et al.The 2001 Bethesda System:terminology for reporting results of cervical cytology.JAMA,2002,287:2114-2119.
  • 2World Health Organization Reproductive Health and Research,Chronic Diseases and Health Promotion.Comprehensive cervical cancer control:a guide to essential practice.Geneva:World Health Organization,2006:15.
  • 3Carolyn Y,Muller,John O,et al.BRCAPAP:feasibility of clinical implications BRCA testing on liquid-based cervical cytology:for biomarker development.Cancer Epidemiol Biomarkers Prey,2004,13:1534-1537.
  • 4Malle D,Pateinakis P,Chakka E,et al.Experience with a thin-layer,liquid-based cervical cytologic screening method.Acta Cytol,2003,47:129-134.
  • 5舒红,李中魁,高霭峰,吕庆杰,霍云龙.宫颈细胞学涂片27404例临床病理分析[J].中国现代医学杂志,2008,18(19):2841-2843. 被引量:9
  • 6梅平,刘艳辉,庄恒国,曾仁海,张威,陈国艳,钱德英.1747例宫颈阴道病变筛查结果分析[J].临床与实验病理学杂志,2005,21(1):70-72. 被引量:31

二级参考文献16

  • 1李茜西.229例宫颈不典型鳞状上皮细胞的患者临床及病理分析[J].广西医学,2005,27(12):1996-1997. 被引量:5
  • 2郝丽军,赫平,李联坤,李雪梅,张新.宫颈上皮内瘤变108例临床分析[J].中国现代医学杂志,2006,16(2):267-269. 被引量:15
  • 3金英杰,王小敏,陈玲.宫颈上皮内瘤样病变筛查10050例及临床诊疗分析[J].齐齐哈尔医学院学报,2006,27(5):513-515. 被引量:7
  • 4Hutchinson ML,Isenstein LM,Goodman A,et al. Homogeneous sampling accounts for the increased diagnostic accuracy using the ThinPrep Proceccor[J]. Am J Clin Pathol,1994,101:215-9.
  • 5Bernstein SJ,Sanchez-Ramos L,Ndubisi B,et al. Liquid-based cervical cytologic smear study and conventional Papanicolaou smears: a metaanalysis of prospective studies comparing cytologic diagnosis and sample adequacy[J]. Am J Obstet Gynecol,2001,185(2):308-17.
  • 6Nygard JF,Sauer T,Skjeldestad FE,et al. CIN2/3 and cervical cancer after ASCUS pap smear. A 7-year,prospective study of the Norwegian population-based,coordinated screening program[J]. Acta Cytol,2003,47:991-1000.
  • 7Fallani MG,Penna C,Fambrini M,et al. Cervical cytologic reports of ASCUS and LSIL. Cyto-histological correlation and implication for management[J]. Minerva Ginecol,2002,54(3):263-9.
  • 8WANG SS, SHEMAN ME, HILDE SHEIM A, et al. Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in United States for 1976-2000[J]. Cancer, 2004, 100(5): 1035-1044.
  • 9SMITH JH. Bethesda 2001[J]. Cytopathology, 2002, 13(1): 4-10.
  • 10SARAIYA M, AHMED F, KRISHNAN S, et al. Cervical cancer incidence in a prevaccine era in the United States, 1998-2002 [J]. Obstet Gynecol, 2007, 109(2 Pt 1): 360-370.

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