摘要
目的 评价液基薄层细胞学检测(TCT)在子宫颈病变筛查中的意义。方法采用TCT系统采集子宫颈细胞学标本4234例,按照TBS系统(theBesthesdasystem)进行判读。对细胞学筛查为异常的272例[意义不明确的非典型性鳞状细胞(ASC—US)或以上病变]进行阴道镜下活组织病理检查。结果TCT与阴道镜下活组织病理检查结果符合率为低度鳞状上皮内病变(LSIL)85.71%(12/14)、高度鳞状上皮内病变(HSIL)100%(20/20)、鳞状细胞癌(SCC)75.00%(3/4)、腺癌(AC)100%(2/2)。TCT诊断不除外高级别鳞状上皮内病变的非典型性鳞状细胞(ASC—H)以上病变的阳性率为23.16%(63/272),活检病理组织学诊断子宫颈上皮内瘤样低度病变(CINI)以上病变的阳性率为24.26%(66/272),二者比较差异无统计学意义(X2=0.868,P=0.581)。结论TCT与活组织病理检查诊断有较高的符合率,二者结合能大大提高对子宫颈的高度病变和子宫颈癌的检出率,减少漏诊。TCT可作为子宫颈癌及癌前病变筛查的一种高效、便捷的方法。
Objective To estimate the clinical value of thinprep cytologic test (TCT) in screening cervical lesion. Methods 4234 TCT samples were interpreted according to the Besthesda System (TBS), 272 positive cases (ASC-US or above) were taken colposcopie examination and biopsy. Results The coincidence of the results between TCT and biopsy in low-grade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), squamous cell carcinoma (SCC), adenocarcinoma (AC) were 85.71% (12/14), 100 % (20/20), 75 % (3/4) and 100 % (2/2), respectively. The positive rates of over ASC-H by TCT and of over CIN I by biopsy were 23.16 % (63/272) and 24.26 % (66/272), respectively. There is no difference between two positive rates (X2 = 0.868, P = 0.581). Conclusion TCT and histopathological diagnosis had a high coincidence, a combination of both can greatly enhance HSIL and cervical cancer and reduce the incidence of missed diagnosis. TCT would be a rapid and convenient method for screening cervical cancer.
出处
《肿瘤研究与临床》
CAS
2011年第3期176-178,共3页
Cancer Research and Clinic
关键词
子宫颈肿瘤
组织细胞学制备技术
诊断
Uterine cervical neoplasms
Histocytological preparation techniques
Diagnosis