摘要
目的探讨添加免疫营养强化剂的胃肠外营养(PN)对肝癌术后患者细胞免疫功能的影响。方法将纳入研究的对象随机分为4组,Ⅰ组单给予PN,Ⅱ组给予含有精氨酸的PN,Ⅲ组给予含有谷氨酰胺的PN,Ⅳ组给予含有精氨酸和谷氨酰胺的PN,检测手术前、后各组患者外周血中CD3+、CD4+、CD8+水平变化。另外选取20例行开腹胆囊切除的患者,测定其入院淋巴细胞免疫功能水平作为正常参照组(对照组)。结果肝癌患者CD3+、CD4+的水平明显低于对照组,CD8+水平高于对照组,差异有统计学意义(P<0.05);Ⅱ、Ⅲ、Ⅳ组术后细胞免疫水平高于Ⅰ组,Ⅳ组术后细胞免疫水平明显高于Ⅰ、Ⅱ、Ⅲ组,差异有统计学意义(P<0.05)。结论免疫营养强化剂的PN可以有效地提高机体的免疫水平,联合精氨酸、谷氨酰胺的PN优于单用一种免疫制剂的PN。
Objective To explore the effect of the immune nutrition enhanced parenteral nutrition （PN） to the cellular immune function of the liver cancer patients after the operation. Methods The cases included in the study were randomly dividcd inlo four groups. Those in the first group were only given PN,group＇s Ⅲ patients were given PN with arginine,group Ill＇s cases were given PN with glutamine,group IV was treated with PN containing arginine and glutamine. The levels of CD3＋ ,CD4＋ and CD8 in pe ripheral blood were detected before and after the surgery. Results The levels of CD3＋ ,CD4＋ in the liver cancer group were signifi cantly higher than those of the control group,CD8＋ level was lower than the control group. Statistical analysis showed they had a statistically significance（P〈0.05） ;the level of cellular immunity in group Ⅱ,Ⅲ and Ⅳ was higher than that of group Ⅰ after the operation,and the level of cellular immunity of group IV was significantly higher than the group Ⅰ, Ⅱ and Ⅲ ,all of which showed statistical significance（P〈0.05）. Conclusion The immune nutrition enhance gastrointestinal nutrition can effectively improve the body＇s immune level, which has better effect when combined with arginine and glutamine than a single immune agent.
出处
《重庆医学》
CAS
CSCD
北大核心
2011年第11期1079-1080,1083,共3页
Chongqing medicine
关键词
胃肠外营养
精氨酸
谷氨酰胺
肝肿瘤
免疫
parenteral nutrition
arginine
glutamine
liver neoplasms
imonunity
