摘要
目的：探讨 Ｌ岩藻糖在肿瘤免疫中所起的作用。方法：对６６ 例成人口腔恶性肿瘤患者和 ５５ 名健康成人，采用浅见直法测定其血清 Ｌ岩藻糖含量。同时对其中的３０ 例患者和正常人通过测 Ｏ Ｄ５７０值来计算细胞毒指数。结果：患者组的血清 Ｌ岩藻糖含量为（１８１７±５９６）μｇ／ Ｌ，细胞毒指数为（０６３±０１１）。明显高于对照组的（８８±１９４）μｇ／ Ｌ及（０１１±００５）， Ｐ＜ ００１，两者相关系数ｒ＝ － ０４３，ｔｒ＝ ２２９， Ｐ＜ ００５。结论：口腔癌患者血清 Ｌ岩藻糖含量及肿瘤坏死因子活性均较正常人明显增高，且两者间呈较密切的负相关关系，提示 Ｌ岩藻糖在肿瘤免疫中可能起某种抑制性作用。
Objective:The papar was to explore the tumor immunological role played by L fucose in oral malignant tumors. Methods:We assayed the serum protein bound L fucose in 66 adults with oral malignant tumors and 55 normal people. The activity of tumor necrosis factor (TNF) was examined in 30 patients and normal people from them. Results:The level of serum L fucose in patients (18.17±5.98)μg/L(P<0.01) was significantly higher than that in normal group (8.8±1.94)μg/L(P<0.01) The level of L fucose in sera was positively correlated with the clinical stages of the patients. The cytotoxic index (CI) value in oral cancer (0.16±0.01) was significantly different from that in the normal (0.11±0.05)(P<0.01). Conclusion:Elevated L fucose level in sera might play some immunosuppressive role in oral malignant tumors.\;Conclusion:Elevated L fucose level in sera might play some immunosuppressive role in oral malignant tumors.\;Elevated L fucose level in sera might play some immunosuppressive role in oral malignant tumors.\;
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1999年第4期278-279,共2页
Journal of China Medical University
关键词
口腔肿瘤
岩藻糖
肿瘤坏死因子
oral malignant tumor
L fucose
tumor necrosis factor
