摘要
皮下注射小檗碱明显减少醋酸性小鼠扭体反应次数,半数有效量为3.5mg/kg,仅在皮下注射8mg/kg的大剂量时,对热板法实验表现出镇痛作用。口服60mg/kg 小檗碱明显抑制醋酸提高小鼠腹腔毛细血管通透性;皮下注射20和50mg/kg都显著抑制组胺提高大鼠皮肤毛细血管通透性。给小鼠皮下注射4和8mg/kg小檗碱显著抑制二甲苯引起耳壳肿胀;给大鼠皮下注射20和40mg/kg时显著抑制角叉菜胶引起的足跖肿胀,作用持续7小时以上。小檗碱的消炎镇痛作用随剂量增大而增加。
Berberine sulfate (Ber) given subcutaneously, significantly decreased acetic acid—induced writhing frequency in mice. The median effective analgesic dose (ED_(50)) of Ber was found to be 3.5 mg/kg. At a larger dose(8mg/kg), assayed with hot plate method, Ber was shown to have analgesic effect in mice. Ber administered orally or subcutaneously, inhibited markedly the increased vascular permeability induced by acetic acid in mice or by histamine in rats. Ber given subcutaneosly (4 and 8 mg/kg), produced obvious inhibition in the xylene—induced swelling of mouse ear. Ber given subcutaneously (20 and 40 mg/kg), inhibited markedly the edema of hind paw produced by carrageenin in rats, the inhibitory effect lasted over seven hours. The anti—inflammatory and analgesic actions of Ber increased with the increasing of dose.
出处
《天然产物研究与开发》
CAS
CSCD
1990年第1期49-53,共5页
Natural Product Research and Development
关键词
小檗碱
消炎
止痛
berberine,anti-inflamma tory agents,analgesics
